Purpose: Anisodine hydrobromide (Ani) is isolated from the medicinal plant Anisodus tanguticus (Maxim.) Pascher for clinical use. Although considerable research regarding Ani has been reported, the safety profiles of Ani are currently unknown. This study investigated the cardiorespiratory effects of Ani in conscious dogs to provide clinicians a detailed safety profile of Ani on the cardiorespiratory system. Materials and Methods: Using the Latin square design, the study was divided into six phases, where in each phase, six telemetered beagle dogs received one dose of normal saline or sotalol hydrochloride or Ani (0.1, 0.4, 1.6, or 6.4 mg/kg). Electrocardiogram, blood pressure (BP) and respiratory parameters were collected before and after administration for 24 hours. Statistical comparisons were performed at scheduled time-points. Results: The heart rate was significantly increased, PR and QT C V intervals were significantly shortened in Ani 0.4, 1.6, 6.4 mg/kg treatment group after drug administration. Compared with the saline group, a significant increase in heart rate and shortening of PR, QT C V intervals were observed in the Ani 1.6, 6.4 mg/kg treatment groups from 5 min to 4 h time-points. Diastolic and mean BP were significantly increased in Ani 1.6, 6.4 mg/kg from 1 h to 2 h time-points compared to those of the saline control. Accelerated breathing was observed in the first 20 min after Ani 0.4, 1.6, and 6.4 mg/kg treatment, although not statistically significant. Furthermore, no significant differences were observed in any of the corresponding indexes of Ani 0.1 mg/kg treatment group at different time-points compared to those of the saline group. Conclusion: Ani may have adverse effects on the cardio-respiratory systems of dogs at doses above 0.4 mg/kg, whereas Ani 0.1 mg/kg was devoid of potentially deleterious effects on cardiorespiratory function.
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机译：目的：从药用植物Anisodus翘曲物（Maxim。）Pascher中分离出含硅氧烷氢溴酸盐（ANI），用于临床使用。虽然报告了关于ANI的相当大的研究，但ANI的安全概况目前未知。本研究调查了ANI在有意识的狗中的心肺作用，为临床医生提供了对心肺系统ANI的详细安全谱。材料和方法：采用拉丁方形设计，将该研究分为六个阶段，在每相中，六只遥测比犬犬接受一剂生理盐水或盐酸盐或AnI（0.1,0.4,1.6，或6.4mg / kg ）。在给药前后收集心电图，血压（BP）和呼吸参数24小时。在预定时间点进行统计比较。结果：药物速率显着增加，ANI和QT C V间隔显着缩短了药物管理后的ANI 0.4,1.6,6.4mg / kg治疗组。与盐碱组相比，在ANI 1.6,6.4mg / kg处理基团中观察到PR，QT C V间隔的心率显着增加，从5分钟到4小时的时间点。与盐水对照相比，舒张压和平均BP在1小时至2小时的时间点中显着增加，6.4mg / kg。在ANI 0.4,1.6和6.4mg / kg处理后，在前20分钟中观察到加速呼吸，虽然没有统计学意义。此外，与盐碱组相比，在不同时间点的任何相应指标中没有观察到在不同时间点的任何相应指标中没有显着差异。结论：ANI可能对0.4mg / kg的剂量的狗的心脏呼吸系统产生不利影响，而ANI 0.1 mg / kg对心肺功能的潜在有害作用缺乏。
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