In this study, a mouthpiece type biosensor using uric acid oxidase (uricase) was developed to measure uric acid in saliva. The mouthpiece biosensor used to monitor salivary uric acid, which has been reported to correlate with blood uric acid levels. The characteristics of the fabricated biosensor were examined based on phosphate buffer solution and artificial saliva. As a result, the mouthguard sensor could quantify the uric acid concentration in the range of 0.1-10 μmol/L. This mouthpiece biosensor will provide useful method for unrestricted and non-invasive saliva uric acid monitoring.
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