Background: Indications for a breath test (BT) are well established in the symptomatic patient with risk factors predisposing them to small intestinal bacterial overgrowth (SIBO). Characteristics and the profile of this population are not well known. Our objective was to study the characteristics of patients undergoing a BT for SIBO and to identify factors associated with a positive BT. Methods: Retrospective study was conducted from 2012 to 2016 at the neurogastroenterology unit of the Centre Hospitalier de l’Universite de Montreal (CHUM). All patients who completed a BT (lactulose and/or glucose) were included. Demographics and clinical factors were analyzed to identify predictors of positive BT. Type of antibiotic treatment and clinical response were compiled. Groups of patients with (SIBO ) and without SIBO (SIBO - ) were also compared. Results: A total of 136 patients were included in the study (mean age 51.2, range 20 - 80 years; 63% women), and SIBO was detected in 33.8% (n = 46). Both groups were similar in terms of age, body mass index, and gender. SIBO was significantly associated with the presence of abdominal pain (odds ratio (OR) = 4.78; P 0.05), bloating (OR = 5.39; P 0.05), smoking (OR = 6.66; P 0.05), and anemia (OR = 4.08; P 0.05). No association was identified with gender, age, obesity, and risk factors for SIBO. Antibiotics were used in 43% of patients with a positive BT, but clinical response was not significantly different in the subgroup that received antibiotics versus the subgroup that did not. Conclusions: The prevalence of SIBO is high in symptomatic patients who underwent breath testing. Abdominal pain, bloating, smoking, and anemia are strongly associated with SIBO. Treatment of SIBO with antibiotics needs to be further investigated to better determine its efficacy on gastrointestinal symptoms.
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机译：背景：呼吸试验（BT）的适应症在症状患者中，具有危险因素，危险将它们置于小肠细菌过度生长（SIBO）。这种人口的特征和概况并不众所周知。我们的目的是研究经过SIBO接受BT的患者的特征，并鉴定与阳性BT相关的因素。方法：回顾性研究于2012年至2016年，在中心住院主管德蒙特利尔（CHUM）的神经科学生学单位进行。包括完成Bt（乳糖和/或葡萄糖）的所有患者。分析人口统计和临床因素以鉴定阳性BT的预测因子。编制抗生素治疗和临床反应的类型。还比较了（SIBO）和没有SIBO（SIBO - ）的患者组。结果：研究中共有136名患者（平均年龄51.2，范围20 - 80岁; 63％的女性），并在33.8％（n = 46）中检测到SIBO。两组在年龄，体重指数和性别方面都相似。 SIBO与腹痛的存在显着相关（差异比（或）= 4.78; p <0.05），膨胀（或= 5.39; p <0.05），吸烟（或= 6.66; p <0.05）和贫血（或= 4.08; p <0.05）。没有与SIBO的性别，年龄，肥胖和危险因素确定的关联。在43％的患者中使用抗生素，患有阳性BT的患者，但临床反应在接受抗生素与亚组的亚组中没有显着差异。结论：在呼吸检测的症状患者中，SIBO的患病率高。腹痛，腹胀，吸烟和贫血与SIBO强烈相关。需要进一步调查用抗生素治疗SIBO，以更好地确定其对胃肠道症状的疗效。
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