The objective of this study was to investigate the existing factors that affect English medium of instruction in Injibara College. In this study, descriptive survey method was employed. Through stratified sampling 145 graduate students (72 male, and 73 female) from natural science, mathematics, language and social science, health and physical education departments were involved in the study. Questionnaire and focus group discussion were employing to collect data. The result of the study showed that students have positive attitude towards English as the medium of instruction. However, foreign language anxiety, English proficiency, shortage of learning resources, and deprived modular preparations were challenged English as the medium of instruction at large. Hence, English as the medium of instruction obstruct students and teachers in teaching learning process. Henceforth, further research would be conducting in English as the medium of instruction in general, within quality education in particular.
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