Omics-based approach in characterising mechanisms of entomopathogenic fungi pathogenicity: A case example of <ce:italic>Beauveria bassiana</ce:italic>

Nazmi Harith-Fadzilah; Idris Abd Ghani; Maizom Hassan

摘要

Biopesticides are gaining interests as an alternative to chemical-based pesticides for arthropod pest management. Among the widely-used biopesticides is the entomopathogenic fungiBeauveria bassianadue to its efficacy and broad range of arthropod hosts. Although the general mechanisms of infection byB. bassianaare known, the underlying complexity of molecular mechanisms at each infection stage is largely not well-understood. Characterising the mechanisms of pathogenicity allows for a more effective pest control by synergising between multiple pesticides or biopesticides without overlapping modes of action and by characterising novel toxic molecules that can expand the biopesticide arsenal. Systems biology refers to a large scale, high-throughput analysis of biological molecules at the systemic level. It incorporates the ‘omics’ methods, allowing identification of genes (genomics), along with their RNA (transcriptomics), proteins (proteomics) and metabolites (metabolomics) expression levels. The high-throughput research approach accelerates the process of characterising pathogenicity. The use of omics is a powerful tool to drive the discovery of the complex process ofB. bassianainfections. This review categorises infection processes into distinct steps, and presents the overview of the genes, proteins and metabolite expressions relevant for theB. bassianapathogenicity.

机译：生物科农药正在获得利益作为用于节肢动物害虫管理的化学杀虫剂的替代品。在广泛使用的生物生物学中是昆虫致病性血统嗜血浴，其疗效和广泛的节肢动物宿主。虽然感染Byb的一般机制。贝斯安纳雷已知，每个感染阶段的分子机制的潜在复杂性在很大程度上是不太理解的。表征致病机制允许通过在多种杀虫剂或生物生物之间的协同作用而不重叠的作用模式和表征可以扩大生物特子砷的新毒性分子之间进行协同作用，允许更有效的害虫控制。系统生物学是指全身水平在生物分子的大规模，高通量分析。它包含“常规”方法，允许鉴定基因（基因组学），以及其RNA（转录组织），蛋白质（蛋白质组学）和代谢物（代谢组）表达水平。高通量研究方法加速了表征致病性的过程。 omics的使用是一个强大的工具，可以推动发现复杂过程的发现。贝斯安佛。该审查将感染过程分为不同的步骤，并概述了对TH的基因，蛋白质和代谢物表达的概述。巴西尾原致病性。

Omics-based approach in characterising mechanisms of entomopathogenic fungi pathogenicity: A case example of Beauveria bassiana

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