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>The possible role of vitamins E and C in reducing the toxicity of copper nanoparticles in the kidney and liver of the rats ( Rattus norvegicus)
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The possible role of vitamins E and C in reducing the toxicity of copper nanoparticles in the kidney and liver of the rats ( Rattus norvegicus)
This study aims to ascertain the extent of accumulation of copper in the tissue of kidneys and liver, in addition to elucidate the effects of toxic nanoparticles on the kidneys and liver’s functions. Also it aims to measure some of the standards of antioxidants. We randomly had divided 56 rats (Rattus norvegicus) weigh 120?g?±?10?g into seven treatment groups and one of them is a controller. Rats in treatment groups were given 100?mg/kg/day of copper nanoparticles and 250?mg/kg/day of vitamins E and C.The obtained results had indicated an accumulation of copper nanoparticles in the liver and kidneys of the rats in the treatment groups. We also found that the accumulation in the liver is significantly more than in the kidneys. Treatment also resulted in the increase of ALT, AST and GGT enzymes level and serum urea and creatinine in blood serum in the copper nanoparticles treated groups. Also there’s increase in level of lipid peroxide and decrease in the level of glutathione in the liver and the kidneys. When we made a comparison between the controlled group with the treated groups by nanoparticle and vitamins, the results had confirmed the effective role of vitamins as antioxidants that reduce the accumulation of nanoparticles in tissues, and returns the level of liver enzymes, Kidney function, lipid peroxide and glutathione to almost normal levels.
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机译：本研究旨在确定肾脏和肝脏组织中铜积聚的程度，除了阐明有毒纳米粒子对肾脏和肝脏功能的影响。它还旨在衡量一些抗氧化剂标准。我们随机分为56只大鼠（Rattus Norvegicus）重量120？G？±10？10？其中一个是控制器。给予治疗组的大鼠100？Mg / kg /天的铜纳米颗粒和250〜Mg / kg /天的维生素E和C.所得结果表明铜纳米粒子在肝脏和肾脏的肝脏和肾脏中的积累治疗组。我们还发现肝脏的积累显着超过肾脏。治疗也导致Alt，AST和GGT酶水平和血清血清中的血清尿素在铜纳米粒子处理的基团中的增加。此外，脂质过氧化物水平增加，肝脏和肾脏水平降低。当我们通过纳米粒子和维生素与治疗组进行对照组进行比较时，结果证实了维生素作为抗氧化剂的有效作用，从而减少组织中纳米颗粒的积累，并返回肝酶，肾功能，脂质水平的抗氧化剂过氧化物和谷胱甘肽几乎正常水平。
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