Preoperative diagnosis of periprosthetic joint infection (PJI) is important because of the therapeutic consequences. The aim of the present study is to investigate whether the serum C-reactive protein (CRP) level can be used as a screening tool for late PJI. A cohort of 390 patients with revision surgery of total hip prostheses (200) or total knee prostheses (190) was assessed for late PJI by determining CRP serum level and performing preoperative aspiration with cultivation and intraoperative tissue analyses with cultivation and histologic examination, using the Musculoskeletal Infection Society (MSIS) and International Consensus Meeting (ICM) criteria. A total of 180 joints were rated as PJI (prevalence 46%). Of these, 42.8% (77) showed a CRP level below 10 mg/L and 28.3% (51) showed a normal CRP level of less than 5 mg/L. The 76.9% of the cases with slow-growing bacteria showed a CRP level below 10 mg/L, and 61.5% showed a normal CRP level. Serum CRP level should not be used as a screening tool to rule out late PJI. Level 2 (diagnostic study).
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机译：由于治疗性后果，术前诊断（PJI）是重要的。本研究的目的是探讨血清C-反应蛋白（CRP）水平是否可用作PJI晚期的筛选工具。通过测定CRP血清水平并通过培养和组织学检查进行培养和术中组织分析，评估PJI晚期PJI的390名患有总髋关节假体（200）或全膝关节前患者（190）的390名患者（190）的群组。使用肌肉骨骼感染协会（MSIS）和国际共识会议（ICM）标准。总共180个关节被评为PJI（患病率46％）。其中，42.8％（77）显示CRP水平低于10mg / L，28.3％（51）显示正常的CRP水平小于5mg / L. 76.9％的患者慢生长细菌显示出低于10mg / L的CRP水平，61.5％显示正常的CRP水平。血清CRP水平不应用作排除PJI晚期的筛选工具。 2级（诊断研究）。
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