...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Emerging Infectious Diseases >Effectiveness and Tolerability of Oral Amoxicillin in Pregnant Women with Active Syphilis, Japan, 2010–2018
【24h】

Effectiveness and Tolerability of Oral Amoxicillin in Pregnant Women with Active Syphilis, Japan, 2010–2018

机译：日本活跃梅毒，日本，日本孕妇中口服阿莫西林的有效性及耐受性，2010-2018

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We conducted a nationwide retrospective study in Japan to evaluate the effectiveness of oral amoxicillin or ampicillin as alternatives to injectable benzathine penicillin G for treating pregnant women with syphilis and preventing congenital syphilis (CS). We investigated 80 pregnant women with active syphilis treated with amoxicillin or ampicillin during 2010-2018. Overall, 21% (15/71) had pregnancies resulting in CS cases, and 3.8% (3/80) changed therapies because of side effects. Among 26 patients with early syphilis, no CS cases occurred, but among 45 with late syphilis, 15 (33%) CS cases occurred. Among 57 patients who started treatment 60 days before delivery, 8 (14%) had CS pregnancy outcomes. We found oral amoxicillin potentially ineffective for preventing CS cases among pregnant women with late syphilis but potentially effective in those with early syphilis. Prospective studies are needed to definitively evaluate the efficacy of amoxicillin for the treatment of pregnant women with syphilis to prevent CS.
机译：我们在日本进行了全国回顾性研究，以评估口服阿莫西林或氨苄青霉素作为注射苯甲苯胺林G用于治疗梅毒治疗孕妇的替代品，并预防先天性梅毒（CS）。我们在2010-2018期间调查了80名患有Amoxicillin或氨苄青霉素的活性梅毒的孕妇。总体而言，21％（15/71）怀孕导致CS病例，3.8％（3/80）因副作用而改变疗法。在26例早期梅毒患者中，没有CS病例发生，但在晚期梅毒中，15例（33％）CS病例发生。在递送前60天开始治疗的57名患者中，8（14％）有CS妊娠结果。我们发现口腔阿莫西林可能无效，无法预防梅毒晚期孕妇的CS案例，但潜在于早期梅毒的妇女。需要预期的研究，以确定阿莫西林对梅毒治疗孕妇治疗的疗效，以预防CS。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号