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首页> 外文期刊>Frontiers in Psychology >Interaction Effects of Life Events and Hair Cortisol on Perceived Stress, Anxiety, and Depressive Symptoms Among Chinese Adolescents: Testing the Differential Susceptibility and Diathesis-Stress Models
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Interaction Effects of Life Events and Hair Cortisol on Perceived Stress, Anxiety, and Depressive Symptoms Among Chinese Adolescents: Testing the Differential Susceptibility and Diathesis-Stress Models

机译：生命事件和头发皮质醇对中国青少年感知压力，焦虑和抑郁症状的互动影响：测试差动易感性和素质应力模型

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The present study aimed to examine whether the activity of the hypothalamic pituitary adrenal axis (HPA) can serve as a physiological marker of the differential susceptibility model or the diathesis-stress model by exploring the interactive effect of life events and hair cortisol on perceived stress, anxiety and depression symptoms among Chinese adolescents. Participants were 324 students in the senior high school. They reported their psychological states with questionnaires at their first semester after the three-month adaptation and provided their 1-cm hair segments closest to the scalp two weeks later. Hair cortisol concentration as a biomarker of the HPA activity was measured with high-performance liquid chromatography tandem mass spectrometry. The results revealed that the interaction between academic events and hair cortisol was significant in predicting adolescents’ perceived stress, anxiety and depression symptoms. There was also a significant interaction between interpersonal events and hair cortisol in predicting adolescents’ anxiety symptoms. The approach of region of significance, the proportion of interaction index and the proportion affected index revealed that adolescents with higher cortisol level were at risk for higher perceived stress and more anxiety symptoms under high academic events, and were in favor for lower perceived stress and less anxiety symptoms under lower academic events. Adolescents with higher cortisol level were in favor for less anxiety symptoms under higher interpersonal events, but were at risk for more anxiety symptoms under lower interpersonal events. Additionally, adolescents with higher cortisol level were at risk for more depression symptoms under higher academic events. These results suggested that the HPA activity might be a physiological marker of the differential susceptibility model for perceived stress and anxiety symptoms, and might be a physiological marker of the diathesis-stress model for depression symptoms among Chinese adolescents.
机译：本研究旨在通过探索生命事件和头发皮质醇对感知压力的互动效果，检查下丘脑垂体肾上腺轴（HPA）的活性是否可以作为差分敏感模型或液质应激模型的生理标志物。中国青少年焦虑和抑郁症状。参与者是高中的324名学生。他们在三个月适应后的第一个学期报告了他们的心理状态，并在两周后提供了最接近头皮的1厘米的头发段。用高效液相色谱串联质谱法测量作为HPA活性的生物标志物的头发皮质醇浓度。结果表明，学术事件和头发皮质醇之间的相互作用在预测青少年的感知，焦虑和抑郁症状方面是显着的。人际赛事和头发皮质醇之间也存在显着的相互作用在预测青少年的焦虑症状方面。重要性的方法，相互作用指数比例和染色指数的比例显示，具有较高的皮质醇水平的青少年在高学术事件中具有更高的感知压力和更焦虑症状的风险，并且有利于降低感知的压力和更少较低学术活动下的焦虑症状。具有较高皮质醇水平的青少年有利于更高的人际关系事件下的焦虑症状，但在较低的人际关系事件下有更多焦虑症状的风险。此外，具有较高的皮质醇水平的青少年在高等教育事件下有更多的抑郁症状患有风险。这些结果表明，HPA活性可能是感知应激和焦虑症状的差异敏感性模型的生理标志，并且可能是中国青少年抑郁症状抑郁症状的生理标志。

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