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首页> 外文期刊>Case Reports in Pediatrics >COVID-19-Associated Multisystem Inflammatory Syndrome Complicated with Giant Coronary Artery Aneurysm
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COVID-19-Associated Multisystem Inflammatory Syndrome Complicated with Giant Coronary Artery Aneurysm

机译：Covid-19相关的多系统炎症综合征复杂于巨冠状动脉动脉瘤

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In the early stages of the outbreak of the novel coronavirus disease 2019 (COVID-19), it was assumed that this infection is very mild and uncommon in children. However, recent reports have shown that children may also develop the disease and its severe complications. These complications included shock, multisystem inflammatory syndrome in children (MIS-C), and pneumonia in children. A previously healthy 14-month-old boy presented with fever, irritability, and skin rash, besides changes in the lips, conjunctiva, and tongue. His medical history, clinical presentations, treatment, laboratory data, and follow-up information were recorded. He was treated according to the diagnosis of Kawasaki disease (KD). He had a history of close contact with a COVID-19 patient. However, the result of reverse transcription-polymerase chain reaction (RT-PCR) assay for COVID-19 was negative. Immunoglobulin M for COVID-19 was positive (1.20), while immunoglobulin G was negative (0.37). Three weeks later, seroconversion of COVID-19 immunoglobulin G (1.42) occurred. Despite treatment with two doses of intravenous immunoglobulin and methylprednisolone, coronary artery ectasia was detected. On the sixth day of hospitalization, the patient experienced hypotension, which necessitated treatment with inotropic drugs and resulted in a change of diagnosis to MIS-C. The later echocardiography showed evidence of coronary artery aneurysm (CAA), which finally changed to giant CAA. Although the patient was treated with infliximab, the size of CAA showed a significant decrease in the one-month follow-up. This is the first report of MIS-C during the COVID-19 pandemic in Iran, accompanied by KD, which was complicated with giant CAA.
机译：在新型冠状病毒疾病爆发的早期阶段2019（Covid-19），假设儿童感染非常温和，罕见。然而，最近的报道表明，儿童也可能发展疾病及其严重并发症。这些并发症包括儿童（MIS-C）的休克，多系统炎症综合征，以及儿童肺炎。除了嘴唇，结膜和舌头的变化，一个以前健康的14个月大的男孩呈现出发烧，烦躁和皮疹。记录了他的病史，临床演示，治疗，实验室数据和后续信息。他根据Kawasaki疾病（KD）的诊断治疗。他有与Covid-19患者密切接触的历史。然而，对Covid-19的逆转录聚合酶链反应（RT-PCR）测定的结果为阴性。用于Covid-19的免疫球蛋白M是阳性的（1.20），而免疫球蛋白G为阴性（0.37）。三周后，发生了Covid-19免疫球蛋白G（1.42）的血清转化。尽管用两种剂量的静脉内免疫球蛋白和甲基己酮醇进行治疗，但检测到冠状动脉区胞外。在第六天的住院治疗中，患者经历了低血压，这需要用渗透药物治疗，导致诊断到MIS-C。后来的超声心动图显示了冠状动脉动脉瘤（CAA）的证据，最终变为巨型CAA。虽然患者用英夫利昔单抗治疗，但CAA的大小表现出一个月的随访中显着降低。这是伊朗Covid-19大流行期间Mis-C的第一份报告，伴随着KD，这与巨型CAA复杂化。

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