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Bartonella-Associated Endocarditis with Severe Active Crescentic Glomerulonephritis and Acute Renal Failure

机译:Bartonella - 相关的心内膜炎,具有严重的活性性新月状肾小球肾炎和急性肾功能衰竭

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We report a case of severe acute kidney failure due to crescentic glomerulonephritis who presented initially with culture-negative endocarditis with vegetations on the aortic valve. Anti-nuclear and anti-phospholipid antibodies were positive with initially negative anti-neutrophil cytoplasmic antibodies (ANCAs). Kidney biopsy revealed severe acute crescentic glomerulonephritis with mesangial immune complex deposition. PR3-ANCA subsequently become positive, and the patient developed worsening kidney failure requiring hemodialysis. This case illustrates that Bartonella can present as culture-negative endocarditis with severe crescentic glomerulonephritis with positive PR-3 ANCAs and can mimic ANCA-associated crescentic glomerulonephritis.
机译:我们举报了由于新月状肾小球肾炎的严重急性肾功能衰竭,最初用培养阴性心内膜炎与主动脉瓣上的植被呈现。 抗核和抗磷脂抗体初始与初始阴性抗中性粒细胞细胞质抗体(ANCAS)阳性。 肾脏活检显示严重的急性新月状肾小球肾炎,具有髓质免疫复合物沉积。 PR3-ANCA随后变为阳性,患者发育了需要血液透析的肾功能衰竭。 这种情况说明Bartonella可以作为培养阴性心内膜炎,具有严重的新月形肾小球肾炎,具有阳性PR-3 ANCAS,可模仿ANCA相关的新月形肾小球肾炎。

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