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首页> 外文期刊>Parkinson’s Disease >Intraoperative Quantitative Measurements for Bradykinesia Evaluation during Deep Brain Stimulation Surgery Using Leap Motion Controller: A Pilot Study
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Intraoperative Quantitative Measurements for Bradykinesia Evaluation during Deep Brain Stimulation Surgery Using Leap Motion Controller: A Pilot Study

机译：使用跨运动控制器深脑刺激手术期间Bradykinesia评估的术中定量测量：试验研究

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Deep brain stimulation (DBS) has shown a remarkably high effectiveness for Parkinson's disease (PD). In many PD patients during DBS surgery, the therapeutic effects of the stimulation test are estimated by assessing changes in bradykinesia as the stimulation voltage is increased. In this study, we evaluated the potential of the leap motion controller (LMC) to quantify the motor component of bradykinesia in PD during DBS surgery, as this could make the intraoperative assessment of bradykinesia more accurate. Seven participants with idiopathic PD receiving chronic bilateral subthalamic nucleus deep brain stimulation (DBS) therapy were recruited. The motor tasks of finger tapping (FT), hand opening and closing (OC), and hand pronation and supination (PS) were selected pre- and intraoperatively in accordance with the Movement Disorder Society revision of the Unified Parkinson's Disease Rating Scale. During the test, participants performed these tasks in sequence while being simultaneously monitored by the LMC and two professional clinicians. Key kinematic parameters differed between the preoperative and intraoperative conditions. We suggest that the average velocity ( ) and average amplitude ( ) of PS isolate the bradykinetic feature from that movement to provide a measure of the intraoperative state of the motor system. The LMC achieved promising results in evaluating PD patients’ hand and finger bradykinesia during DBS surgery.
机译：深脑刺激（DBS）对帕金森病（PD）显示出显着高的有效性。在DBS手术期间的许多PD患者中，通过评估刺激电压增加，通过评估Bradykinesia的变化来估算刺激测试的治疗效果。在这项研究中，我们评估了在DBS手术中量化Pd中Bradykinesia的电机组分的潜力，因为这可能使得Bradykinesia更准确地进行术中评估。招募了七位参与者接受慢性双侧亚粒细胞核深脑刺激（DBS）治疗的患者。敲击手指的运动任务（FT），手开合（OC），和手旋前，旋后（PS）选择前和术中按照统一的帕金森病评分量表的运动障碍协会修订。在测试期间，参与者按顺序执行这些任务，同时由LMC和两个专业临床医生同时监控。关键运动学参数在术前和术中条件之间不同。我们建议PS的平均速度（）和平均幅度（）与该运动中的Bradykinetic特征隔离，以提供电动机系统的朝内状态的量度。 LMC实现了有希望在DBS手术期间评估PD患者的手和手指Bradykinesia。

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