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首页> 外文期刊>Journal of nanomaterials >Propofol Combined with Fentanyl Is Superior to Propofol Alone in Sedation Protocols for Painless Gastrointestinal Endoscopy
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Propofol Combined with Fentanyl Is Superior to Propofol Alone in Sedation Protocols for Painless Gastrointestinal Endoscopy

机译：异丙酚与芬太尼联合优于异丙酚，单独在镇静方案中单独用于无痛的胃肠内窥镜检查

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Sufficient propofol or fentanyl doses necessary to prevent the response to skin incision do not necessarily reduce hemodynamic responses during surgery. The purpose of this study was to characterize the pharmacodynamic interaction between propofol and fentanyl with respect to the sedative effects and safety during painless gastrointestinal endoscopy. From October 2018 to October 2020, 200 patients undergoing painless gastrointestinal endoscopy in our department’s outpatient or inpatient clinic were selected and randomly divided into a control group and an observation group, 100 patients per group. Prior to surgery, the patients in the two groups were required to be connected to an electrocardiogram monitor and then were instructed to lie on the left side and receive continuous oxygen infusion of 2-3?L/min with a nasal cannula. The control group was injected with propofol injection (100?mg/min). The observation group was given fentanyl intravenous injection at a dose of 0.1? μ g/kg followed by propofol injection (100?mg/min). Painless gastrointestinal endoscopy was performed after the patients entered a sleep state and the eyelash reaction disappeared. Outcome analysis was performed on preoperative and intraoperative hemodynamic indicators, including heart rate, blood oxygen saturation, dose of propofol, time for endoscopy, recovery time, hospitalization after recovery, Montreal Cognitive Assessment (MoCA) score, and Mini-Mental State Examination (MMSE) score. The incidence rate of adverse reactions in the observation group was 6%, which was notably lower than that of the control group (18%). The total response rate of the observation group was 98%, which was significantly higher than that of the control group (90%) ( ). The intraoperative heart rate and blood oxygen saturation of the observation group were higher than those of the control group ( ). The patients receiving sedation with propofol plus fentanyl had fewer doses of propofol and shorter recovery time than those receiving propofol alone ( ). It was also revealed that the patients receiving sedation with propofol plus fentanyl exhibited more MoCA and MMSE scores than those receiving propofol alone 30?min after sedation during painless gastrointestinal endoscopy. Taken together, sedation with propofol combined with fentanyl was more effective and safer than that with propofol alone in painless gastrointestinal endoscopy, which can ensure a wake-up state, stable breathing cycle, and better gastrointestinal painless procedure.
机译：必须在手术期间不一定减少对皮肤切口的响应所需的足够的异丙酚或芬太尼剂量不一定减少血液动力学反应。本研究的目的是在无痛胃肠内窥镜检查期间表征异丙酚和芬太尼之间的药效学相互作用。从2018年10月到2020年10月，选择了我们部门门诊或住院内诊断的200名患者，并随机分为对照组和观察组，每组100名患者。在手术之前，需要两组的患者被要求连接到心电图显示器，然后指示左侧位于左侧，并在鼻腔插管接收连续的氧输注2-3Ω·l / min。用异丙酚注射注射对照组（100μmg/ min）。观察组在0.1的剂量下给予芬太尼静脉注射剂？ μg/ kg，然后是异丙酚注射（100？mg / min）。在患者进入睡眠状态后进行无痛胃肠内镜检查，睫毛反应消失。结果分析是对术前和术中血液动力学指标进行的，包括心率，血氧饱和度，丙酚剂量，内窥镜检查时间，恢复后的恢复时间，住院时间，蒙特利尔认知评估（MOCA）评分和迷你精神状态检查（MMSE ） 分数。观察组不良反应发生率为6％，显着低于对照组（18％）。观察组的总反应率为98％，显着高于对照组（90％）（）。观察组的术中心率和血氧饱和度高于对照组（）的血氧饱和度。接受苯丙酚加芬太尼接受镇静的患者具有比接受异丙酚（）的较少剂量的异丙酚和较短的恢复时间（）。还透露，接受镇静剂与芬太尼接受镇静的患者表现出更多的MOCA和MMSE谱，而不是在沉陷的胃肠内镜内窥镜检查期间镇静后接受异丙酚30〜min。一起服用镇静与芬太尼联合芬太尼更有效和比单独的异丙酚在无痛的胃肠内镜内窥镜中更有效，可以确保唤醒状态，稳定的呼吸循环和更好的胃肠无痛手术。

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