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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Prospective Cohort Study Comparing Varying Doses of Cisatracurium and Atracurium on Intubating Conditions in Patients Undergoing Laparoscopic Cholecystectomy
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Prospective Cohort Study Comparing Varying Doses of Cisatracurium and Atracurium on Intubating Conditions in Patients Undergoing Laparoscopic Cholecystectomy

机译：对腹腔镜胆囊切除术患者的平顺性曲静脉和休蒽酮的预期队列研究比较

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Cisatracurium and atracurium are nondepolarising muscle relaxants belonging to benzylisoquinolinium group.Intubating dose of cisatracurium is found to be safer than atracurium owing to the histamine release and resultant respiratory and cardiac side-effects associated with the latter.However, intubating conditions of twice the ED95 dose (2xED95) of cisatracurium are not as satisfactory as equipotent dose of atracurium because of its higher potency.Aim: To compare the time of onset, intubating conditions and mean duration of action of three and four times ED95 doses (3 and 4xED95) of cisatracurium with 2xED95 dose of atracurium so as to find out an ideal intubating dose of cisatracurium that is comparable with 2xED95 of atracurium.Materials and Methods: The present study was a prospective cohort study that included 102 patients who underwent elective laparoscopic cholecystectomy.They were divided into three groups of 34 each to receive atracurium 0.5 mg/kg (group A), cisatracurium 0.15 mg/kg (group B) or cisatracurium 0.2 mg/kg (group C) for intubation.Onset and duration of neuromuscular block were assessed using Train Of Four (TOF) stimuli.Total time for intubation and mean intubation scores were also noted.Statistical analysis was done using Statistical Package for the Social Sciences (SPSS) software version 18.0.Qualitative data were compared using Chi-square test and quantitative data compared using Analysis of Variance (ANOVA).Results: Onset of neuromuscular blockade in groups A, B and C were 292.06±61.486, 204.71±39.407 and 120.88±37.284 seconds (p-value <0.001), respectively.Mean intubation score was highest in group C along with least intubating time (p-value <0.001).The mean duration of action in groups A, B and C were 40.44±5.275, 48.24±5.888 and 63.38±7.659 minutes, respectively (p-value <0.001).Conclusion: The 3 and 4xED95 doses of cisatracurium are superior to 2xED95 dose of atracurium in providing faster onset of action, better intubating conditions, shorter intubation time and longer duration of action.The 4xED95 dose of cisatracurium may be considered for rapid intubation in two minutes.
机译：Cisatracurium和Atracurium是属于苄基喹啉基团的肌肉松弛剂。由于组胺释放和与后者相关的呼吸道和心脏副作用，发现奇碱的肌肉尿素的用途更安全。然而，ED95剂量的两倍的插管条件（2×95）的顺式饱和尿剂不如昂贵的休息剂量令人满意，因为其较高的效力。优势：比较起始时间，插管条件和均线的均匀持续时间（3次）的纱索尿酸钠（3和4xED95）含有2×95剂的atracurium，以了解一个理想的插管剂量，与2×95的atracurium.materials和方法相当：本研究是一项前瞻性队列研究，包括102名接受腹腔镜胆囊切除术的患者。他们分为三组34群接受Atracurium 0.5 mg / kg（A组），顺​​列0.15用于插管的Mg / kg（B组）或顺式0.2mg / kg（c组）。使用四（TOF）刺激的火车评估神经肌肉嵌段的组成和持续时间。还注意到插管的时间时间和平均插管分数。统计使用统计包来进行分析，用于社会科学（SPSS）软件版本18.0.使用Chi-Square测试和定量数据使用差异分析（ANOVA）的定量数据进行比较。结果：A组，B组中神经肌肉封锁的发作C分别为292.06±39.407和120.88±37.284秒（p值<0.001），分别在C组中具有最高的容纳时间（p值<0.001）。平均行动持续时间在A组中，B和C分别为40.44±5.275,48.24±5.888和63.38±7.659分钟（P值<0.001）。结论：3和4×4×4xED95剂量的顺式饱和剂优于2×95剂atracurium，提供更快的发作行动，更好的插管条件，嘘兽人插管时间和较长的作用持续时间。4×95剂的顺式饱和尿剂可以考虑在两分钟内快速插管。

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