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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Detection of?Helicobacter pylori?in Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders at a Tertiary Care Centre in Gujarat: A Case-Control Study
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Detection of?Helicobacter pylori?in Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders at a Tertiary Care Centre in Gujarat: A Case-Control Study

机译：检测幽门螺杆菌？在古吉拉特第三次护理中心的口腔鳞状细胞癌和口腔潜在恶性障碍中：一个病例对照研究

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Oral squamous cell carcinoma (OSCC) contribute to 90% of cancer cases in head and neck region and entails remarkable morbidity and mortality inspite of immense research and advances.Amongst other causes, infection with Helicobacter pylori is an emerging cause of OSCC.There is still perplexity in the exact etiopathogenesis of H.pylori related oral cancer.Aim: In order to explore this much unattended area, present study was aimed to find out the association between H.pylori in premalignant disorders and OSCC.Materials and methods: A Prospective case-control Pilot study of 35 patients (11 confirmed cases of Oral squamous cell carcinoma and 24 with oral potentially malignant disorders along with 15 age and sex matched healthy control) from June 2018 - September 2018 was conducted in the Department of Microbiology, Smt.B.K.Shah Medical Institute, Piparia, Gujarat.H.pylori was detected by methods like Rapid urease test, Gram’s staining and Serology.Results: H.pylori was detected in five cases with OSCC with male predominance and mean age 45.6 yrs.All the five positive patients were severely addicted to tobacco and betel quid since decades.Tobacco was found to be the major risk of OSCC with the OD of 16.19, followed by betel quid (OD-4.56) and H.pylori infection (OD-0.83).Conclusion: The results of this pilot study do not establish a definite causal relationship between H.pylori and OSCC due to the low sample size.Study definitely offers an avenue for further work on larger populations to confirm this possible association.
机译：口腔鳞状细胞癌（OSCC）有助于90％的癌症病例的头部和颈部地区，并且具有巨大的发病率和巨大的研究和造成的巨大研究，而且是其他原因，幽门螺杆菌感染是OSCC的新兴原因。在H.Pylori相关口腔癌症的确切病因发生中的困惑。为了探索这种无人看管的地区，目前的研究旨在发现H.Pylori在毛发发性疾病和OSCC之间的关联。重要的情况和方法：一个潜在的案例 - 从2018年6月到2018年6月 - 2018年9月在微生物学，SMT.BK部门开展了35名患者的35例患者的试验研究（11例患有口腔鳞状细胞癌和24例，以及性别匹配的健康控制）在MICT.BK Shah医学研究所，Piparia，Gujarat.h.Pylori被快速脲酶测试，克的染色和血清学检测到方法。结果：H.Pylori在五个案例中被检测到与Maly Pritomance的OSCC均为45.6 YRS。从数十年来，这五名阳性患者沉迷于烟草和槟榔。被认为是OSCC的主要风险，其它是16.19的ODER，其次是Betel Quid（OD -4.56）和H.Pylori感染（OD​​-0.83）。结论：由于样品尺寸低，该试点研究的结果不会在H.Pylori和OSCC之间建立明确的因果关系.Study绝对是提供进一步工作的大道在较大的人口上确认这种可能的关联。

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