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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Neutrophil-to-Lymphocyte and Plateletto-Lymphocyte Ratio in Adult-Onset Still Disease, their Relationship with Baseline Disease Activity and Subsequent Disease Course: A Retrospective Cohort Study
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Neutrophil-to-Lymphocyte and Plateletto-Lymphocyte Ratio in Adult-Onset Still Disease, their Relationship with Baseline Disease Activity and Subsequent Disease Course: A Retrospective Cohort Study

机译：中性粒细胞到淋巴细胞和血小板淋巴细胞比例在成人症仍然疾病中，它们与基线疾病活动和随后的疾病课程的关系：回顾性队列研究

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Adult-onset Still Disease (AoSD) is a rare systemic polygenic non-familial autoinflammatory disease of unknown aetiology.The long-term course of the disease can be categorised in three different definitions including self-limited course, intermittent course or chronic course.Recently, Neutrophilto-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) were investigated in various rheumatic diseases as an informative markers in evaluating severity of inflammation and disease activity.Aim: To explore association between baseline NLR, PLR, disease activity score and subsequent disease course in patients with AoSD.Materials and Methods: This retrospective cohort study enrolled 61 patients with AoSD and 61 age-matched patients with Fibromyalgia Syndrome (FMS).Pouchot score was specifically used in AoSD patients to assess disease activity based on symptoms, physical examination findings and laboratory results from April 2020 to July 2020.Patients with AoSD were subgrouped into three groups: self-limited; intermittent; and chronic course.The association of NLR and PLR with disease activity score was analysed between groups by using independent samples t-test, Mann-Whitney U test and Kruskal Wallis Variance Analysis.Differences between categorical variables were analysed using Chi-square test.A p≤0.05 was considered statistically significant.Results: The mean follow-up of the 61 patients with AoSD was 74 months (range, 14-169).Eighteen patients (29.5%) had a self-limited disease course, nine patients (14.8%) an intermittent disease course and 34 (55.7%) a chronic disease course.AoSD patients had significantly higher serum NLR, PLR and lower Mean Platelet Volume (MPV) values than FMS patients {6.68 (1.67-19.7), 1.83 (1.1-4) p=0.0001; 187 (82.9-549), 114 (72-246) p=0.0001; 8.3 (6.4-11.3), 9.3 (7.7-11.7) p=0.0001, respectively}.NLR, PLR and Pouchot score were similar among AoSD subgroups, which were grouped according to disease pattern.The majority of patients in the self-limited and chronic course groups had higher baseline Pouchot score without statistical significance.The NLR and C-Reactive Protein (CRP) were significantly higher in AoSD patients with active disease than inactive disease {7.02 (1.8-19.7), 4.17 (1.67-14.8) p=0.06; 13 (1.9-29.5), 9 (1.6-20.9) p=0.046, respectively)}.Conclusion: High NLR and elevated CRP levels are related to active disease in AoSD patients.Although NLR, PLR and Pouchot score were similar among subgroups, patients with a chronic course or self-limited course had higher NLR values and more active disease at diagnosis compared with patients with an intermittent course.
机译：成人发病仍然疾病（AOSD）是一种罕见的全身性多基因无家族性自身炎症性炎症性炎症性疾病。该疾病的长期过程可以分为三种不同的定义，包括自限制课程，间歇性课程或慢性课程。 ，在各种风湿性疾病中研究了中性粒细胞淋巴细胞比（NLR）和血小板到淋巴细胞比（PLR）作为评估炎症和疾病活动的严重程度的信息标志物。探讨基线NLR，PLR，疾病活动之间的关联AOSD患者的分数和随后的疾病课程和方法：这项回顾性队列研究招收了61例AOSD和61例纤维肌痛综合征患者（FMS）。适用于AOSD患者的AOSD评分，以评估基于的疾病活动症状，体检发现和实验室结果从2020年4月到7月2020日。与AOSD的患者亚组分为三个G. ROUP：自我限制;间歇性;和慢性课程。通过使用独立样本T检验，曼诺 - 惠特尼测试和Kruskal Wallis方差分析分析了NLR和PLR与疾病活动分数的关联。使用Chi-Square Test.A分析了分类变量之间的分析.A P≤0.05被认为是统计学意义。结果：61例AOSD患者的平均随访时间为74个月（范围，14-169）.eighteen患者（29.5％）具有自动有限的疾病课程，九名患者（14.8 ％）间歇性疾病课程和34（55.7％）慢性疾病疗程。患者患者显着高于FMS患者的血清NLR，PLR和低平均血小板体积（MPV）值{6.68（1.67-19.7），1.83（1.1- 4）P = 0.0001; 187（82.9-549），114（72-246）P = 0.0001; 8.3（6.4-11.3），9.3（7.7-11.7）p = 0.0001，分别} .nlr，plr和袋子分数在AOSD亚组中相似，根据疾病模式分组。自我限制和患者中的大多数患者慢性课程群体具有更高的基线囊分数而不统计显着性。AOSD活性疾病患者的NLR和C反应蛋白（CRP）显着高于非活性疾病{7.02（1.8-19.7），4.17（1.67-14.8）P = 0.06; 13（1.9-29.5），9（1.6-20.9）P = 0.046分别）}。结论：结论：高NLR和升高的CRP水平与AOSD患者的活跃疾病有关。虽然NLR，PLR和PICHOT得分在亚组中相似，慢性课程或自动限制课程的患者在诊断中具有较高的NLR值和更具活跃的疾病，而与间歇性课程相比。

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