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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Apelin 13 and Blood Pressure, Is there any Association in Pre-eclampsia? A Case-control Study
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Apelin 13 and Blood Pressure, Is there any Association in Pre-eclampsia? A Case-control Study

机译：Apelin 13和血压，在预先引发前有什么关联吗？ 病例对照研究

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Pre-eclampsia is a pregnancy specific disorder, characterised by the onset of hypertension and proteinuria.Preeclampsia is the leading cause of maternal, perinatal morbidity and mortality.The exact cause of pre-eclampsia is not known clearly and needs to be explored.Aim: To evaluate the maternal serum apelin 13 levels among pre-eclampsia and healthy pregnant women and also, to find the association between apelin 13 and blood pressure.Materials and Methods: A case-control study was conducted between Department of Biochemistry and Department of Obstetrics and Gynaecology, RL Jalappa Hospital and Research Centre, Kolar, Karnataka, India.After approval from the Institutional Ethics Committee and written informed consent from study subjects, a total of 270 pregnant women were recruited for this study.Among them, 135 pre-eclamptic women were considered as cases and 135 normotensive healthy pregnant women served as controls.According to the pre-eclampsia severity, cases were grouped into mild (n=47) and severe preeclampsia (n=88).Blood samples were collected from all the study subjects and was analysed for apelin 13 by Enzyme Linked Immunosorbent Assay (ELISA) method.Maternal and foetal adverse outcomes were recorded.Results were expressed as mean±Standard Deviation (SD).Categorical variables were expressed in percentages.Spearman’s correlation was applied and p<0.05 was considered significant.Results: The mean gestational age was 36.66±3.69 weeks which was, significantly low in pre-eclamptic women compared with healthy pregnant women.BMI (26.94±3.81 kg/m2 ), systolic (157.82±15.14 mmHg), diastolic (101.68±11.02 mmHg) and Mean Arterial Pressure (MAP) (120.20±11.12 mmHg), pulse rate (88.14±5.82 bpm), Aspartate Transaminase (AST) (25.25±12.49 IU/L) and Alanine Transaminase (ALT) (19.01±10.95 IU/L) were significantly increased in pre-eclamptic women when compared with control group.Mean maternal serum apelin 13 (341.44±218.63 pg/mL) concentrations were significantly lower in pre-eclampsia compared with healthy pregnant women.Maternal serum apelin 13 concentrations were negatively correlated with Systolic Blood Pressure (SBP) (r=-0.196), Diastolic Blood Pressure (DBP) (r=-0.172) and MAP (r=-0.204).Adverse maternal outcomes such as epigastric pain 75 (55.55%), oedema 62 (45.92%) and persistent headache 35 (25.92%) were higher in pre-eclamptic group.Additionally, adverse foetal outcomes were more in preeclamptic cases including significantly decreased birth weight (2.40±0.65), babies requiring Neonatal Intensive Care Unit (NICU) admission were 54 (40%), preterm birth (≤37 wks) in 50 (37.03%), Respiratory Distress Syndrome (RDS) 31 (22.96%), Small for Gestational Age (SGA) in 4 (2.96%) and Intra Uterine Death (IUD) in 11 (8.14%) neonates.Conclusion: It was concluded from the present study that there was low maternal serum apelin 13 concentrations in pre-eclampsia and had negative correlation with blood pressure, suggesting its potential role in the pathophysiology of pre-eclampsia.
机译：预先引发前妊娠特异性疾病，其特征在于高血压和蛋白尿.Preeclampsia是孕产妇，围产期发病率和死亡率的主要原因。预先普利坦斯的确切原因是清楚的，需要探索。为了评估母体血清Apelin 13水平，也可以在孕妇孕妇和健康的孕妇中，找到阿蛋白13和血压之间的关联。材料和方法：在生物化学和产科部门之间进行案例对照研究妇科，RL Jalappa医院和研究中心，Kolar，Karnataka，印度。在制度伦理委员会批准和书面知情同意的批准中，招募了270名孕妇为这项研究招募了270名孕妇。Among他们，135名Eclampe妇女被认为是案件，135名正常健康的孕妇作为对照。根据异国普拉克斯预先的严重程度，病例被分组为轻微（n = 47）和严重的预胰抗（n = 88）。从所有研究受试者中收集的样品，并通过酶联免疫吸附测定（ELISA）方法分析阿贝林13.记录的目标和胎儿不良结果。表达了结果和胎儿不良结果。表达了结果。结果作为平均值±标准偏差（SD）。特异性变量以百分比表示。应用了施用的相关性，P <0.05被认为是显着的。结果：平均妊娠期为36.66±3.69周，比较了生态蛋白前女性显着低。比较孕妇健康孕妇.BMI（26.94±3.81 kg / m2），收缩压（157.82±15.14 mmHg），舒张压（101.68±11.02 mmHg）和平均动脉压（MAP）（120.20±11.12mmHg），脉搏率（88.14±5.82与对照组的对照组相比，在对照组母体血清Apelin 13（ 341.44±218.63 pg / ml）浓度显着降低与健康孕妇相比预先普利坦斯。与收缩压（SBP）（R = -0.196），舒张压（DBP）（R = -0.172）和地图（R = -0.204）和地图（R = -0.204）和地图（R = -0.204）和地图（R = -0.204）和地图（R = -0.204）和地图（R = -0.204）和地图（R = -0.204）和地图（R = -0.204）和地图（R = -0.204）和地图（R = -0.204 ）。诸如外延疼痛75（55.55％），水肿62（45.92％）和持续性头痛35（25.92％）的孕产妇结果较高（25.92％）较高（25.92％）。加盟，在预克切式案件中，不良胎儿结果包括明显减少出生体重（2.40±0.65），需要新生儿重症监护室（NICU）入场的婴儿54（40％），早产（≤37周），50（37.03％），呼吸窘迫综合征（RDS）31（22.96％）在11名（2.96％）和子宫内死亡（IUD）中的胎龄（SGA）小（8.14％）新生儿。结论：从本研究中得出结论，母体血清Apelin 13浓度葛兰素和血压与血压负相关，表明其在疾病中的潜在作用预先征收前的标识。

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