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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Vitamin B12 Deficiency in Eastern India: A Hospital Based Cross-sectional Study
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Vitamin B12 Deficiency in Eastern India: A Hospital Based Cross-sectional Study

机译：印度东部的维生素B12缺乏：基于医院的横断面研究

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The prevalence of vitamin B12 deficiency is common (around 40%) in people older than 65 years of age and in people who are strict vegetarians.The major sources of Viamin B12 are meat, fish, dairy products and fortified cereals.Aim: To study the prevalence and common types of presentations of vitamin B12 deficiency among 20-80 years aged, nonvegetarian people attending a tertiary care hospital in a state of Eastern India.Materials and Methods: This hospital based cross-sectional study was conducted at IPGME&R and SSKM Hospital between July 2018 to December 2019.Serum samples were collected from 478 adult patients presenting with different symptoms like pallor, fatigue, numbness and tingling sensation in limbs, memory loss, alopecia etc., which may be related to vitamin B12 deficiency.These samples were screened for serum vitamin B12 level by chemiluminescence method in ADVIA, Centaur CP (SIEMENS).Data were analysed statistically by graph pad prism 8 software.Significance of the difference between means were detected using Student’s unpaired t-test and calculating the p-value (p-value <0.05 were considered as significant).Results: Among 184 females, 50 (27.17%) were found to be Vitamin B12 deficient (VBD).Among them, 18 (36%) had mild deficiency (serum vitamin B12 level 201-220 pmol/L), 22 (44%) had moderate (serum vitamin B12 level 150-200 pmol/L) and 10 (20%) had severe deficiency (serum vitamin B12 level <150 pmol/L).A total of 35 (70%) of the VBD females were of <50 years of age.Among 294 males, 83 (28.23%) were found to be VBD.Among them, 34 (41%) had mild deficiency (serum vitamin B12 level 201-220 pmol/L), 36 (43%) had moderate (serum vitamin B12 level 150-200 pmol/L) and 13 (16%) had severe deficiency (serum vitamin B12 level <150 pmol/L).Total 43 (51.8%) of VBD male persons were of <50 years age.Among VBD female patients, 24 (48%) had neuropathy and among VBD male patients, 54 (65%) had neuropathy.Conclusion: So, it can be concluded that if regular screening is done for serum vitamin B12 in symptomatic patients irrespective of age, a number of problems can be reduced or cured by diagnosing VBD patients and treating them with vitamin B12 either by dietary modification or medicinal supplementation.
机译：维生素B12缺乏的患病率是65岁的人和严格素食主义者的人群常见（约40％）。Viamin B12的主要来源是肉类，鱼类，乳制品和强化谷物。至关重要：要学习20 - 80年代维生素B12缺乏症的患病率和常见类型，非终徒人们在印度时代的第三级护理医院参加了第三级护理医院。材料和方法：本医院的横断面研究是在IPGME＆amp; R和2018年7月至2019年12月之间的SSKM医院。从478名成年患者中收集了患有不同症状的478名样本，如脓液，疲劳，麻木和刺痛感，内存丧失，脱发等可能与维生素B12缺乏有关。这些通过在Advia，Centaur CP（西门子）的化学发光方法筛选样品的血清维生素B12水平.Data通过Graph Pad Prism 8软件分析了Centaur CP（西门子）.Data。差异的焦虑使用学生未配对的T检验检测手段之间的疏忽并计算p值（P值<0.05被认为是有重大的）。结果：在184例女性中，发现50名（27.17％）是维生素B12缺陷（VBD） 。众多，18（36％）有轻微的缺乏（血清维生素B12级201-220 pmol / L），22（44％）中等（血清维生素B12级150-200 pmol / L）和10（20％）缺乏严重的缺陷（血清维生素B12级<150 pmol / l）。总共35％（70％）的VBD女性为<50岁。amgs 294雄性，83名（28.23％）被发现为VBD。其中，34（41％）具有轻度缺乏（血清维生素B12级201-220 pmol / L），36（43％）具有中等（血清维生素B12级150-200 pmol / L）和13（16％）严重的缺乏（血清维生素B12级<150 pmol / L）.ToTal 43（51.8％）VBD男性人员<50岁。Among VBD女性患者，24例（48％）具有神经病和VBD男性患者，54名（65％）具有神经病变。结论：所以，可以得出结论，如果是常规屏幕对于年龄而言，患有血清维生素B12的血清维生素B12是通过诊断或通过膳食改性或药物补充剂治疗维生素B12来减少或治愈的症状患者中的血清维生素B12。

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