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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Group B?Streptococcus?Colonising the Genital Tract of Pregnant Women from Dibrugarh, Assam: Circulating Serotypes, Susceptibility Pattern and Phylogenetic Analysis
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Group B?Streptococcus?Colonising the Genital Tract of Pregnant Women from Dibrugarh, Assam: Circulating Serotypes, Susceptibility Pattern and Phylogenetic Analysis

机译：B组？链球菌？来自Dibrugarh，Assam的孕妇生殖道的殖民：循环血清型，敏感模式和系统发育分析

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Maternal genitalia colonising bacteria i.e., Group B Streptococcus (GBS) well known as Streptococcus agalactiae is responsible for serious health complications in newborns like sepsis, meningitis and pneumonitis.Centre for Disease Control and Prevention (CDC) recommends a thorough culture based screening in 35-37 weeks gestation mothers for further therapeutic steps.Previously no study was carried out on the occurrence of GBS among pregnant mothers in Assam with phylogenetic analysis.Aim: To bring the scenario of GBS infection in antepartum women by targeting the capsular serotypes with their antibiogram profile and to bring the phylogenetic relationship of the prevailing GBS isolates found in Dibrugarh district, Assam, India.Materials and Methods: This was a hospital based observational study which was carried out in District Urban Health Centre, Assam, India.Lower vaginal swabs without using speculum were collected from the enrolled late trimester pregnant women.Socio-demographic data were collected with their consent.Out of the total enrolled participants (n=345), GBS was isolated in 52 samples.These were inspected by culture techniques and further confirmed using molecular methods.Serotyping was carried out by employing multiplex PCR.Antibiotic susceptibility test was conducted as per Clinical and Laboratory Standards Institute (CLSI) guidelines and phylogenetic tree was reconstructed.Data analysis was done using Statistical Package for the Social Sciences (SPSS) version 16.0.Results: This study showed a GBS carriage rate of 15.1% in the colonising participating women.No significant association with any of the demographic and clinical factors was found.Serotype Ia (42.1%) was the ruling one followed by VI (31.6%), II (15.8%) and VII (10.5%).While 36.7% of the GBS isolates were grouped into not typeable.Serotypes Ia showed resistant towards cefotaxime, erythromycin and clindamycin and serotype II towards vancomycin.Phylogenetic evaluation showed the presence of four distinct clusters viz., I, II, III and IV with unique evolutionary trends in human GBS population in the study site.Conclusion: So far in Assam, this study reports for the first time on GBS prevailing rate in late trimester mothers which may be helpful in declining the rate of adverse neonatal outcomes with on time maternal therapeutic administration by real time monitoring of antibiogram profiling.This study also paves a way of designing Capsular Polysaccharide (CPS) based vaccines for immunising the expectant mothers to prevent adverse outcomes of the newborns.
机译：母性生殖器殖民细菌IE，B组链球菌（GBS）均称为链球菌嗜碱症症是对脓毒症，脑膜炎和肺炎等新生儿的严重健康并发症的原因，用于疾病控制和预防（CDC）建议在35-中建议彻底的培养筛查。 37周的妊娠母亲进行进一步治疗步骤。术语不受孕妇发育分析的孕妇中GBS中GBS的出现进行了研究：通过将荚膜血清型与其抗癌血管型靶向患有患有患者的GBS感染的情况并带来Dibrugarh区，阿萨姆，印度的普遍GBS分离物的系统发育关系。这是一家基于医院的观察研究，该研究是在Assam，India的地区城市健康中心进行。阴道拭子而不使用从注册后期孕妇孕妇中收集了窥器。社会人口统计数据被收集的是他们的同意。在52个样品中分离出GBS的总注册参与者（n = 345）。通过培养技术检查，并使用分子方法进一步证实。通过使用多重PCR.antibiotic易感性进行了发现试验按照临床和实验室标准研究所（CLSI）指南和系统发育树进行了重建。使用统计包来进行社会科学（SPSS）版本16.0.0.0.结果：该研究表明，GBS Carrige率为15.1％殖民参与的女性。没有发现与任何人口统计和临床因素有重大联系。菌型IA（42.1％）是统治，其次是VI（31.6％），II（15.8％）和VII（10.5％）。而将36.7％的GBS分离株分为不可典型的。βIA显示出对头孢噻肟，红霉素和克林霉素和血清霉素的血清发育评估表现出f我们独特的群集viz。，I，II，III和IV，研究现场的人类GBS人口独特的进化趋势。结论：到目前为止在阿萨姆姆，这项研究首次在5月下旬苗族苗族的GBS盛行率首次报告有助于通过实时监测抗性孕妇治疗抗体剖析，利用母体治疗给药的不良新生儿结果的速度。本研究还铺设了一种设计荚膜多糖（CPS）的疫苗，以防止预期母亲以防止不良结果新生儿。

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