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首页> 外文期刊>Bone Reports >Performance of two bone substitutes of novel cotton-like β-TCP/PDLGA and granular β-TCP on bone regeneration in the femoral bone defect of the Beagle dogs
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Performance of two bone substitutes of novel cotton-like β-TCP/PDLGA and granular β-TCP on bone regeneration in the femoral bone defect of the Beagle dogs

机译：两种骨替代的新型棉状β-TCP / PDLGA和粒状β-TCP在骨骨缺陷中的骨质再生粒度的性能

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This study aimed to clarify whether novel cotton-like composite made of β-tricalcium phosphate (β-TCP) and poly(Dl-lactide-co-glycolide) (PDLGA) has a different effect onin vivobone regeneration after bone defect than that of granular β-TCP. Five male Beagle dogs served as subjects. Cortical and medullary bone defect as non-through holes were made at the diaphysis of the bilateral femurs. One side was implanted with β-TCP/PDLGA (β-TCP/PDLGA group) and the other side was implanted with granular β-TCP (β-TCP group). At 4?weeks after implantation, we found no significant differences in the percentages of newly formed bone area and fibrous tissue area in the bone defect between the two groups. The β-TCP/PDLGA group showed more uniform filling on the surface and earlier disappearance of the material in the medullary region, and there were fewer inflammatory cells and osteoclasts in the bone defect in the β-TCP/PDLGA group. In conclusion, β-TCP/PDLGA performs better at filling the bone defect uniformly and disappears earlier at the cortical and medullary regions while causing less inflammation and bone resorption. Although bone formation activity of the β-TCP/PDLGA group in the cortical region was lower, the newly formed bone volume in bone defect of the β-TCP/PDLGA group was equal to that of the β-TCP group.
机译：该研究旨在阐明由β-磷酸钙（β-TCP）和聚（D1-丙交酯 - 共乙酰胺）（PDLGA）制成的新型棉状复合材料是否在骨缺损之后具有不同的效果，而不是粒状β-TCP。五只雄猎犬狗作为主题。在双侧股骨的骨干中制作皮质和髓质骨缺陷作为非通孔。将一侧植入β-TCP / PDLGA（β-TCP / PDLGA组），另一侧植入颗粒β-TCP（β-TCP组）。在植入后4周，我们发现两组骨缺损中的新形成的骨面积和纤维组织区域的百分比没有显着差异。 β-TCP / PDLGA基团显示髓质区域中材料的表面和早期消失更均匀，并且β-TCP / PDLGA基团中骨缺损中较少的炎性细胞和骨质体。总之，β-TCP / PDLGA在均匀填充骨缺损时表现较好，并在皮质和髓质区域之前消失，同时导致炎症和骨吸收较少。虽然皮质区域中β-TCP / PDLGA基团的骨形成活性较低，但是β-TCP / PDLGA组的骨缺陷中的新形成的骨体积等于β-TCP组的骨缺陷。

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