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首页> 外文期刊>CHROMATOGRAPHY >Effect of Organic Modifier on the Retention of Low-Molecular-Weight Organic Compounds in Low-Temperature HPLC Using a Liquid CO2 Mobile Phase and an Octadecyl Stationary Phase
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Effect of Organic Modifier on the Retention of Low-Molecular-Weight Organic Compounds in Low-Temperature HPLC Using a Liquid CO2 Mobile Phase and an Octadecyl Stationary Phase

机译：有机改性剂对使用液体CO 2 移动相和十八烷基固定相的低温HPLC在低温HPLC中保持低分子类有机化合物的影响

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摘要

The retention behaviors of various low-molecular-weight compounds in low-temperature HPLC with an ODS (octadecyl silica) column and liquid CO_(2) mobile phase containing methanol or acetonitrile as modifiers were investigated. The addition of methanol/acetonitrile reduced the retention of xanthone, which was dominated by the liquid CO_(2) content, independent of the modifier. Additionally, the retention of polycyclic aromatic hydrocarbons (PAHs) was reduced by the addition of methanol/acetonitrile. Because acetonitrile resulted in a rapid reduction in the retention compared with methanol, it was suggested that the CH-? interactions have an important role in the retention of PAHs in the C18 stationary phase. Notably, the retention of alkylbenzenes were only slightly affected by the addition of methanol/acetonitrile. Acetonitrile slightly increased the retention of alkylbenzenes with longer alkyl chains than those with shorter alkyl chains. It is suggested that the interaction of the phenyl moiety in alkylbenzenes with C18 chains was reduced by the increase in the acetonitrile content, and enhanced in the case of the alkyl chain moieties. The retentions of alkyl benzenes were approximately compensated, when the alkyl chain length was relatively short.
机译：研究了含有ODS（十四烷基二氧化硅）柱和含有甲醇或乙腈作为改性剂的ODS（十四烷基二氧化硅）塔和液体CO_（2）流动相的各种低分子量化合物的保留行为。加入甲醇/乙腈降低了X吨酮的保留，其由液体CO_（2）含量为主，与改性剂无关。另外，通过加入甲醇/乙腈来降低多环芳烃（PAHS）的保留。因为乙腈导致保留的迅速减少与甲醇相比，所以提示CH-？相互作用在C18固定阶段保留PAH中具有重要作用。值得注意的是，通过加入甲醇/乙腈的添加仅略微影响烷基苯的保留。乙腈略微增加烷基苯与较长的烷基链的保留比烷基链更短的烷基链。建议通过增加乙腈含量的增加，减少了苯基部分与C18链的烷基苯的相互作用，并在烷基链部分的情况下增强。当烷基链长度相对较短时，近似补偿烷基苯的固定。

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