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首页> 外文期刊>American Journal of Analytical Chemistry >Elemental Concentrations in Biological Samples of Coronavirus Disease (COVID-19) and Other Pulmonary Disease Patients
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Elemental Concentrations in Biological Samples of Coronavirus Disease (COVID-19) and Other Pulmonary Disease Patients

机译：冠状病毒疾病生物样本中的元素浓度（Covid-19）和其他肺病患者

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Background: Recently, Coronavirus Disease 2019 (COVID-19) has been affected by the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has developed important global health anxiety. At this time, the treatment options for this disease are only moderately successful. Smoking has been related to COVID-19 and its mortality, and it has the potential to affect bacteriological and viral conversion, clinical effects, and treatment outcomes. Methods: The aim of this study was to determine the relationship between critical essential trace {zinc (Zn), iron (Fe), and copper (Cu)} and toxic {cadmium (Cd) and nickel (Ni)} elements in human biological samples such as scalp hair, serum, saliva, blood, nasal fluid, and sputum of smoking and nonsmoking male COVID-19 patients (n = 139, age range 25 - 38 years) from Hyderabad, Pakistan. For comparative purposes, the biological specimens of referent persons (n = 83), pulmonary Tuberculosis (T.B) patients (n = 67), Pneumonia (n = 56) of the same age groups were also be analyzed. Microwave oven mediated digestion method was employed, and digestion of samples was carried out with the help of 2:1 mixture solution of HNO_(3) (65%) and H_(2)O_(2) (30%). Atomic absorption spectrometry was employed for the determination of elemental concentrations from the microwave oven employed digested samples. Results: The found average of essential elements (Zn, Fe, and Cu) in biological specimens of smoker and nonsmoker male COVID-19, T.B, and Pneumonia patients was found to lower, whilst cadmium and nickel were found to be higher when compared with samples from referents (p < 0.001). Conclusions: Improved elemental (Cu, Fe, Zn) concentrations may also decrease the risk of bacterial co-infection by enhancing the mucociliary clearance and respiratory epithelial barrier function, in addition to providing direct antibacterial effects against S. pneumoniae . Our findings also suggest that higher Cd and Ni concentrations are linked to cigarette smoking, which could lead to COVID-19 and other lung-infected diseased recurrences. However, further clinical and experimental research is required.
机译：背景：最近，冠状病毒疾病2019（Covid-19）受到极端急性呼吸综合征冠状病毒2（SARS-COV-2）的影响，并发展了重要的全球健康焦虑。此时，这种疾病的治疗方案仅成功。吸烟与Covid-19有关及其死亡率，它有可能影响细菌学和病毒转化，临床效果和治疗结果。方法：本研究的目的是确定批判基本痕量{锌（Zn），铁（Fe）和铜（Cu）}和毒性{镉（CD）和镍（Ni）}元素之间的关系诸如头皮头发，血清，唾液，血液，鼻腔，鼻腔，吸烟和非摩托人的痰和非莫斯·母科学-19患者（N = 139，25至38岁）的样品从海德拉巴，巴基斯坦。对于比较目的，还分析了该指数（n = 83），肺结核（T.B）患者（n = 67），相同年龄组的肺结核（n = 56）的生物学标本。使用微波炉介导的消化方法，并在2：1的HNO_（3）（65％）和H_（2）O_（2）（30％）的溶液的帮助下进行样品的消化。采用原子吸收光谱法用于测定来自微波炉的元素浓度，所述微波炉采用消化样品。结果：发现吸烟者和非商口雄性Covid-19，TB和肺炎患者的生物标本中的基本元素（Zn，Fe和Cu）的发现平均值，同时发现镉和镍镉和镍较高来自引用的样品（p <0.001）。结论：除了为提供直接抗菌作用外，改善了元素（Cu，Fe，Zn）浓度也可能降低细菌相应的细菌共合的风险。肺炎。我们的研究结果还表明，较高的CD和Ni浓度与香烟吸烟有关，这可能导致Covid-19和其他肺部感染的疾病复发。但是，需要进一步的临床和实验研究。

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