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首页> 外文期刊>Egyptian Journal of Medical Human Genetics >The morbidity and mortality of COVID-19 are correlated with the Ile105Val glutathione S-transferase P1 polymorphism
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The morbidity and mortality of COVID-19 are correlated with the Ile105Val glutathione S-transferase P1 polymorphism

机译：Covid-19的发病率和死亡率与ILE105VAL谷胱甘肽S-转移酶P1多态性相关

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Background:Oxidative stress is an important issue in coronavirus disease 2019 (COVID-19). Considering that glutathione S-transferase P1 (GSTP1) is involved in cellular detoxification, it may play an important role in susceptibility to infection with SARS-CoV-2 and/or its outcome. In the present study, the association between the Ile105Val GSTP1 polymorphism (rs1695) and susceptibility to SARS-CoV-2 infection, as well as its outcome was investigated. Data on the prevalence (per 106 people), case-fatality (per 100 infected cases), and mortality (per 106 people) of COVID-19 and various potential confounders (the life expectancy at birth, density of medical doctors, density of nursing and midwifery personnel, and the gross national income per capita) were used. The latest data available for 45 countries were used for the study.ResultsIn multivariate linear regression analyses, the Val105 allelic frequency showed positive association with the log-prevalence (partial r = 0.308, p = 0.042) and log-mortality of COVID-19 (partial r = 0.316, p = 0.037). The log-fatality did not show association with the allelic frequency. In the next step, only countries with the gross national income per capita more than $15,000 were included in the analysis. In the selected countries, the frequency of Val105 was positively associated with the log-prevalence (partial r = 0.456, p = 0.009) and log-mortality of COVID-19 (partial r = 0.544, p = 0.001).ConclusionsThe present findings indicate that countries with higher Val105 allelic frequency of the rs1695 polymorphism showed higher prevalence and mortality of COVID-19.
机译：背景：氧化胁迫是冠状病毒疾病2019（Covid-19）的重要问题。考虑到谷胱甘肽 S - 转移酶P1（ GSTP1 人），病例（每100个受感染的病例），死亡率（每10 6 人）的covid-19和各种潜力使用混乱（出生时的预期寿命，医学医生密度，护理密度和助产人员，人均国民国内收入率）。 45个国家的最新数据用于研究。鉴定多变量线性回归分析，Val105等位基因频率与逻辑流行率显示阳性关联（部分 R = 0.308， P = 0.042）和Covid-19的对数死亡率（部分 R = 0.316， P = 0.037）。对数死亡率没有显示与等位基频率的关联。在下一步中，只有超过15,000美元的国民国收入总额超过15,000美元的国家。在所选国家，Val105的频率与逻辑流行率呈正相关（部分 r = 0.456， P = 0.009）和Covid-19的日志死亡率（部分 R = 0.544， P = 0.001）。结论，目前的调查结果表明，具有较高VAL105的全国的RS1695多态性频率较高的国家表现出更高的Covid-19的患病率和死亡率。

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