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首页> 外文期刊>EFSA Journal >Safety and efficacy of feed additives consisting of Vitamin B2 (98%) and Vitamin B2 (80%) as riboflavin produced by Bacillus subtilis KCCM 10445 for all animal species (Hubei Guangji Pharmaceutical Co. Ltd.)
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Safety and efficacy of feed additives consisting of Vitamin B2 (98%) and Vitamin B2 (80%) as riboflavin produced by Bacillus subtilis KCCM 10445 for all animal species (Hubei Guangji Pharmaceutical Co. Ltd.)

机译：饲料添加剂的安全性和有效性，包括维生素B2（98％）和维生素B2（80％）作为由Bacillus枯草芽孢杆菌KCCM 10445生产的核黄素，用于所有动物物种（湖北广吉药业有限公司）

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Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of vitamin B2 98% and vitamin B2 80% in the form of riboflavin produced by fermentation with a genetically modified strain of Bacillus subtilis (KCCM 10445) as nutritional additives in feed and water for drinking for all animal species. The production strain harbours antimicrobial resistance genes. With the data available the Panel is not in the position to confirm the correspondence between the strain deposited under accession number KCCM 10445 and the strain under the current assessment. The production strain and its recombinant DNA were not detected in the final products. Therefore, the additives do not pose any safety concern associated with the genetic modification of the production strain. The additives are safe for the target species, the consumer and the environment. Vitamin B2 80% is not hazardous by inhalation. In the absence of data, no conclusions on the possible risk by inhalation of vitamin B2 98% can be reached. Neither vitamin B2 98% nor vitamin B2 80% are irritant to skin or eyes. In the absence of data, no conclusions on the skin sensitisation potential of the additives can be reached. The additives under assessment are effective in covering the animals’ requirements for vitamin B2 when administered via feed and/or water for drinking.
机译：遵循欧盟委员会的要求，动物饲料（进料）中使用的添加剂和产品或物质小组被要求提供对维生素B2 98％的安全性和疗效和维生素B2 80％的科学意见，以核黄素的形式通过发酵产生的枯草芽孢杆菌（KCCM 10445）的遗传修饰菌株作为饲料和水的营养添加剂，用于饮用的所有动物物种。生产菌株患有抗菌性抗性基因。利用可用的数据，面板的位置不在能够在当前评估下沉积在登录号KCCM 10445和应变之间的应变之间的对应关系。在最终产物中未检测到生产菌株及其重组DNA。因此，添加剂不会造成与生产菌株的遗传改性相关的任何安全问题。添加剂对目标物种，消费者和环境是安全的。维生素B2 80％通过吸入而没有危险。在没有数据的情况下，不能得出通过吸入维生素B2 98％可能的风险的结论。既不是维生素B2 98％也没有维生素B2 80％对皮肤或眼睛刺激性。在没有数据的情况下，可以达到添加剂的皮肤致敏电位的结论。评估中的添加剂是在通过饲料和/或饮用水施用时覆盖对维生素B2的动物的要求。

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