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首页> 外文期刊>MBio >Genetic Diversity of Meningococcal Serogroup B Vaccine Antigens among Carriage Isolates Collected from Students at Three Universities in the United States, 2015–2016
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Genetic Diversity of Meningococcal Serogroup B Vaccine Antigens among Carriage Isolates Collected from Students at Three Universities in the United States, 2015–2016

机译：脑膜炎球菌血清血群B疫苗抗原在美国三所大学中的寄生疫苗疫苗抗原，2015-2016

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ABSTRACT Carriage evaluations were conducted during 2015 to 2016 at two U.S. universities in conjunction with the response to disease outbreaks caused by Neisseria meningitidis serogroup B and at a university where outbreak and response activities had not occurred. All eligible students at the two universities received the serogroup B meningococcal factor H binding protein vaccine (MenB-FHbp); 5.2% of students (181/3,509) at one university received MenB-4C. A total of 1,514 meningococcal carriage isolates were obtained from 8,905 oropharyngeal swabs from 7,001 unique participants. Whole-genome sequencing data were analyzed to understand MenB-FHbp’s impact on carriage and antigen genetic diversity and distribution. Of 1,422 isolates from carriers with known vaccination status (726 [51.0%] from MenB-FHbp-vaccinated, 42 [3.0%] from MenB-4C-vaccinated, and 654 [46.0%] from unvaccinated participants), 1,406 (98.9%) had intact fHbp alleles (716 from MenB-FHbp-vaccinated participants). Of 726 isolates from MenB-FHbp-vaccinated participants, 250 (34.4%) harbored FHbp peptides that may be covered by MenB-FHbp. Genogroup B was detected in 122/1,422 (8.6%) and 112/1,422 (7.9%) isolates from MenB-FHbp-vaccinated and unvaccinated participants, respectively. FHbp subfamily and peptide distributions between MenB-FHbp-vaccinated and unvaccinated participants were not statistically different. Eighteen of 161 MenB-FHbp-vaccinated repeat carriers (11.2%) acquired a new strain containing one or more new vaccine antigen peptides during multiple rounds of sample collection, which was not statistically different ( P ?=?0.3176) from the unvaccinated repeat carriers (1/30; 3.3%). Our findings suggest that lack of MenB vaccine impact on carriage was not due to missing the intact fHbp gene; MenB-FHbp did not affect antigen genetic diversity and distribution during the study period.
机译：抽象的运输评估是在2015年至2016年进行的，在两所美国大学期间，与疾病爆发的反应结合疾病爆发，由梅细胞脑霉菌B和一所大学，爆发和反应活动没有发生。两所大学的所有符合条件的学生都接受血清群体B脑膜炎因子H结合蛋白质疫苗（MENB-FHBP）; 5.2％的学生（181/3,509）在一所大学获得MENB-4C。从7,001名独特参与者的8,905个口咽拭子中获得了总共1,514个脑膜炎球菌载体分离物。分析了全基因组测序数据以了解MeNB-FHBP对携带和抗原遗传多样性和分布的影响。来自具有已知疫苗接种状态的载体的1,422个分离物（726 [51.0％]来自MeNB-FHBP接种疫苗，42℃下疫苗接种，来自未接触的参与者的654 [46.0％]），1,406（98.9％）完整的FHBP等位基因（来自MeNB-FHBP接种的参与者716）。来自MeNB-FHBP接种的参与者的726个分离物，250（34.4％）患有MeNB-FHBP的患者覆盖的FHBP肽。在122 / 1,422（8.6％）和112/1,422（7.9％）分离物中，分别检测Genogroup B分别从MeNB-FHBP接种和未接受的参与者分离。 MeNB-FHBP接种和未接受的参与者之间的FHBP亚家族和肽分布并没有统计学不同。 161个MeNB-FHBP接种的重复载体（11.2％）在多轮样品收集期间获得含有一种或多种新疫苗抗原肽的新菌株，其从未涂上的重复载体没有统计学上不同的（p？= 0.3176） （1/30; 3.3％）。我们的研究结果表明，缺乏对托架的疫苗疫苗的影响不是由于缺少完整的FHBP基因; MENB-FHBP在研究期间没有影响抗原遗传多样性和分布。

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