Circular RNAs in cancer and diabetes

ANIMESH HATIBARUAH; MIZANUR RAHMAN; SATYAKAM AGARWALA; SINGH ANI SERAM; SURUCHI GUPTA; PROSENJIT PAUL PAUL

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Circular RNAs in cancer and diabetes

机译：癌症和糖尿病中的圆形RNA

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Circular RNAs (circRNAs) are a class of noncoding RNA molecules formed by the back splicing process. Compared to linear mRNA molecules they are more stable. CircRNA acts as miRNA sponges, regulates translation, epigenetic alterations, etc. However, the most significant aspect of circRNAs has been its role in regulating the hallmark of cancer and diabetes mellitus. Several circRNAs areextensively expressed in individuals with cancer and diabetics. Dysregulated expression of various circRNAs plays a crucial part in the development of type 2 diabetes mellitus. In the present review, we present the current understanding of cricRNAs biogenesis, regulatory mechanisms, reviews of recent findings and circRNA as potential biomarker.

机译：圆形RNA（CircrNA）是一类由后剪接过程形成的非编码RNA分子。与线性mRNA分子相比，它们更稳定。 Circrna充当miRNA海绵，调节翻译，表观遗传改变等，Circrnas最重要的方面是其在调节癌症和糖尿病的标志方面的作用。几个Circrnas在患有癌症和糖尿病患者的个体中表达了一系列。同样的各种Circrnas的表达表达在2型糖尿病的发展中起着至关重要的部分。在本综述中，我们目前了解CRICRNA生物发生，监管机制，最近发现和Circrna的审查作为潜在的生物标志物。

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《Journal of genetics》 |2021年第a期|共10页
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ANIMESH HATIBARUAH; MIZANUR RAHMAN; SATYAKAM AGARWALA; SINGH ANI SERAM; SURUCHI GUPTA; PROSENJIT PAUL PAUL;
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tumourmiRNA spongeback-splicingbiomarker.;

机译：tumourmiRna海绵背 - 劈开斑点斑点。;

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1. Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer (vol 16, pg 2301, 2017) [J] . Lai Zhiyong, Yang Yang, Yan Yichao, Cell cycle . 2018,第2期

机译：圆形RNA和MRNA的共表达网络分析显示，圆形RNASHSA_CIRC_0047905，HSA_CIRC_0138960和HAS-CIRCRNA7690-15是胃癌中的候选癌基因（Vol 16，PG 2301,2017）
2. Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer [J] . Lai Zhiyong, Yang Yang, Yan Yichao, Cell cycle . 2017,第23期

机译：用于圆形RNA和MRNA的共表达网络的分析显示，圆形RNAS HSA_CIRC_0047905，HSA_CIRC_0138960和HAS-CIRCRNA7690-15是胃癌中的候选癌症
3. Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer [J] . Lai Zhiyong, Yang Yang, Yan Yichao, Cell cycle . 2017,第23期

机译：用于圆形RNA和MRNA的共表达网络的分析显示，圆形RNAS HSA_CIRC_0047905，HSA_CIRC_0138960和HAS-CIRCRNA7690-15是胃癌中的候选癌症
4. miRDiabetes: A microRNA-Diabetes Association Database Constructed by Classification on Literature [C] . Hui Guo, Qin Ding International Conference on Bioinformatics and Computational Biology . 2016

机译：MirdiaBetes：由文学分类构建的MicroRNA-糖尿病协会数据库
5. Inflammation, Type 2 Diabetes, and Cancer: Identifying Biomarkers Associated with Colorectal Cancer and Type 2 Diabetes, and the Use of microRna Molecules as a Therapeutic Use for Cancer Treatment [D] . Guillen, Jenni. 2020

机译：炎症，2型糖尿病和癌症：鉴定与结肠直肠癌和2型糖尿病相关的生物标志物，以及使用MicroRNA分子作为癌症治疗的治疗用途
6. Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905 hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer [O] . Zhiyong Lai, Yang Yang, Yichao Yan, 2017

机译：对环状RNA和mRNA的共表达网络的分析表明环状RNA hsa_circ_0047905hsa_circ_0138960和has-circRNA7690-15是胃癌的候选癌基因。
7. Circular RNA HIPK3: A Key Circular RNA in a Variety of Human Cancers [O] . Jingyuan Wen, Jingyu Liao, Junnan Liang, 2020

机译：圆形RNA Hipk3：各种人类癌症中的关键圆形RNA
8. Lung Cancer-Specific Circular RNAs as Biomarkers. [R] . Mo, Y. 2017

机译：肺癌特异性环状RNa作为生物标志物。

Circular RNAs in cancer and diabetes

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