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首页> 外文期刊>Journal of Traditional Chinese Medical Sciences >Dynamic observation of the progression of chronic gastritis to gastric cancer in a disease–TCM pattern rat model
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Dynamic observation of the progression of chronic gastritis to gastric cancer in a disease–TCM pattern rat model

机译：动态观察疾病-TCM模式大鼠模型中慢性胃炎对胃癌的进展

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ObjectiveTo dynamically observe the progression of chronic gastritis to gastric cancer (GC) in disease-traditional Chinese medicine (TCM) pattern rats to provide data for understanding the disease progression and effective approaches for drug screening and mechanism exploration.MethodsWistar rats were randomly divided into control (n?=?96, half female and half male) and model (n?=?336, half female and half male) groups. Model rats received free access to N-methyl-N′-nitro-N-nitrosoguanidine (120?μg/mL), sodium deoxycholate (20?mmol/L), and alcohol (45%), and were subjected to intermittent fasting. Mortality rate, body weight, water consumption, food intake, gastric pathology, blood content analysis, and liver and kidney function of model rats were dynamically monitored over 30 weeks. In the 30thweek, pattern characteristics were assessed. Gastric pathology and pattern characteristics were observed for an additional 8 weeks to evaluate stability.ResultsThe overall mortality of the model group was 34.82% (33.10% for females and 36.55% for males) at 30 weeks post-intervention. Inflammatory cell infiltration, glandular atrophy, atypical hyperplasia, and GC manifested successively in the gastric mucosa of rats. In model rats, N-methyl-N′-nitro-N-nitrosoguanidine intake was lower in males than in females, whereas pathological changes in the gastric mucosa occurred earlier in females than in males. Notably, gastric mucosal lesions were more severe in males than in females. Our modeling methods maintained stable gastric mucosal lesions for at least 8 weeks after final intervention. The pattern characteristics observed in model rats at the 30thand 38thweek were consistent with those of spleen deficiency, blood stasis, and yin deficiency pattern. Blood content and indexes of liver and kidney function in the model group were normal.ConclusionOur findings provide evidence for the pathological stages underscoring the progression of chronic gastritis to GC in disease-TCM pattern rats, which may facilitate development of relevant pharmacotherapies.
机译：atecexiveto在疾病 - 中医（TCM）模式大鼠中动态观察慢性胃炎（GC）的进展，以提供了解疾病进展和药物筛查和机制勘探的有效方法。一般分为对照（n？=α= 96，半雌性和半男性）和模型（n？= 336，半雌性和半男性）组。模型大鼠获得对N-甲基-N'-硝基-N-亚硝基胍（120×μg/ ml）的，脱氧胆酸钠（20×mmol / L）和醇（45％），并进行间歇仓位。在30周内动态监测模型大鼠的死亡率，体重，耗水，食物摄入，胃病变，血液含量分析和肝脏和肾功能。在30周，评估了模式特征。胃肠病理学和模式特征额外8周观察到评估稳定性。在干预后30周，模型组的总体死亡率为34.82％（女性为33.10％，男性36.55％）。炎症细胞浸润，腺体萎缩，非典型增生和GC在大鼠胃粘膜中表现出。在模型大鼠中，雄性中的N-甲基-N'-NITRO-NITROSOGUANIDININ进气体比在女性中较低，而胃粘膜的病理变化在女性中发生比男性更早。值得注意的是，胃粘膜病变在雄性中比女性更严重。我们的造型方法在最终干预后至少8周保持稳定的胃粘膜病变。在38六周的模型大鼠中观察到的模式特征与脾虚，血瘀和阴虚模式一致。模型组中肝脏和肾功能的血液含量和肾功能是正常的.Conclusionour调查结果为病理阶段强调疾病-TCM模式大鼠慢性胃炎进展的证据，这可能促进相关药物治疗的发展。

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