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首页> 外文期刊>E3S Web of Conferences >Study of the human infectious safety model under the influence of SARS-CoV-2 on the example of the Perm Krai of the Russian Federation
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Study of the human infectious safety model under the influence of SARS-CoV-2 on the example of the Perm Krai of the Russian Federation

机译：SARS-COV-2影响下的人类传染性安全模型研究俄罗斯联邦普遍克莱的例子

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摘要

In the new millennium, humanity is faced with infectious diseases that no one previously knew about. In the end of 2019, an outbreak of a new coronavirus infection occurred in the People’s Republic of China (PRC) with an epicenter in the city of Wuhan (Hubei Province). On February 11, 2020, the International Committee on the Taxonomy of Viruses assigned an official name to the infectious agent - SARS-CoV-2. According to the results of serological and phylogenetic analysis, coronaviruses are divided into four genera: Alphacoronavirus, Betacoronavirus, Gammacoronavirus and Deltacoronavirus. Currently, four seasonal coronaviruses (HCoV-229E, - OC43, -NL63 and -HKU1) are circulating among the world’s population, which are present year-round in the structure of ARI, and, as a rule, cause damage to the upper respiratory tract of mild and moderate severity, as well as two highly pathogenic coronaviruses-Middle East respiratory syndrome virus (MERS) and new coronavirus infection COVID-19. To develop a model of human resistance to the disease caused by the coronavirus family, the elements, links and ways of protecting the Human-Virus-Environment system were identified. The destructive functions of sixteen proteins of the SARS-CoV-2 strain are considered. Deterministic and statistical models of cells infection risk development have been developed. A parameterized system of human protection against coronavirus infection is proposed.
机译：在新的千年中，人类面临着没有人认识的传染病。截至2019年底，在中华人民共和国（中国）中，在武汉市（湖北省）的震中发生了新的冠状病毒感染。 2020年2月11日，国际病毒分类委员会将官方名称分配给传染病 - SARS-COV-2。根据血清学和系统发育分析的结果，冠状病毒分为四个属：Alphacoronavirus，Betacoronavirus，γAvirus和deltacoronavirus。目前，四个季节性冠状病毒（HCOV-229E， - OC43，-NL63和-HKU1）在世界的人口中循环，在ARI的结构中全年期间，以及规则导致上呼吸损失细菌和中度严重程度，以及两种高度致病的冠状病毒中东呼吸综合征病毒（MERS）和新的冠状病毒感染Covid-19。鉴定了鉴定了由冠状病毒家族，元素，链接和保护人病毒环境系统引起的人类抵抗疾病的模型。考虑了SARS-COV-2菌株的16个蛋白的破坏功能。已经开发了细胞感染风险发展的确定性和统计模型。提出了针对冠状病毒感染的人体保护参数化系统。

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