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首页> 外文期刊>Clinical Medicine Insights: Reproductive Health >Characteristics of polycystic ovary syndrome throughout life
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Characteristics of polycystic ovary syndrome throughout life

机译：整个生命中多囊卵巢综合征的特征

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Polycystic ovary syndrome is the most common endocrine disorder in women of reproductive age. It is a complex disease in which genetic, endocrine, environmental, and behavioral factors are intertwined, giving rise to a heterogeneous phenotype with reproductive, metabolic, and psychological characteristics. Polycystic ovary syndrome affects women’s health and their quality of life across the life course. During different life stages, the polycystic ovary syndrome phenotype can change, which requires a personalized diagnostic approach and treatment. Polycystic ovary syndrome is a major cause of anovulatory infertility; this disorder is also associated with hirsutism and acne. Diagnosing polycystic ovary syndrome during adolescence is challenging because the polycystic ovary syndrome criteria include normal physiological events that occur during puberty. With increasing age, the syndrome evolves from a reproductive disease to a more metabolic disorder. Along with metabolic disturbances, including insulin resistance and abnormalities of energy expenditure, polycystic ovary syndrome is recognized as a major risk factor for the development of type 2 diabetes and cardiovascular disease in later life. Moreover, there is evidence for familial clustering of endocrine and metabolic features of polycystic ovary syndrome. Environmental factors such as diet and obesity appear to contribute to the phenotype. Treatment should be tailored to the specific concerns and needs of the individual patient and involves restoring fertility, treatment of the metabolic complaints, treatment of androgen excess, and providing endometrial protection. The complexity of the disorder, and the impact on quality of life, requires a timely diagnosis, screening for complications, and management strategies for the long-term health issues associated with polycystic ovary syndrome. The syndrome remains underdiagnosed, and women experience significant delays to diagnosis.
机译：多囊卵巢综合征是生殖年龄妇女中最常见的内分泌疾病。它是一种复杂的疾病，其中遗传，内分泌，环境和行为因素被交织在一起，产生具有生殖，代谢和心理特征的异质表型。多囊卵巢综合征影响妇女的健康状况及其在生命课程中的生活质量。在不同的寿命期间，多囊卵巢综合征表型可以改变，这需要个性化的诊断方法和治疗。多囊卵巢综合征是逆向不孕症的主要原因;这种疾病也与Hirsutism和痤疮有关。诊断青春期期间的多囊卵巢综合征是挑战性，因为多囊卵巢综合征标准包括在青春期期间发生的正常生理事件。随着年龄的增加，综合征从生殖疾病中发展到更新的代谢障碍。除了代谢障碍，包括胰岛素抵抗和能量消耗的异常，多囊卵巢综合征被认为是后期生命中2型糖尿病和心血管疾病的主要危险因素。此外，存在多囊卵巢综合征的内分泌和代谢特征的家族性聚类。饮食和肥胖等环境因素似乎有助于表型。应根据个体患者的具体担忧和需求定制治疗，并涉及恢复生育率，治疗代谢抱怨，治疗雄激素过量，并提供子宫内膜保护。疾病的复杂性以及对生活质量的影响需要及时诊断，筛查并发症，以及与多囊卵巢综合征相关的长期健康问题的管理策略。综合征仍然是未结算的，妇女经历诊断的重大延误。

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