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首页> 外文期刊>American Journal of Nuclear Medicine and Molecular Imaging >Findings from a novel scintigraphic gastroesophageal reflux study in asymptomatic volunteers
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Findings from a novel scintigraphic gastroesophageal reflux study in asymptomatic volunteers

机译：从无症状志愿者进行新的闪烁胃病反流研究的调查结果

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Gastroesophageal reflux disease (GERD) is a common and growing problem in most western countries. It may present with the typical symptoms of heartburn and regurgitation or with the effects of extra-esophageal disease. We have developed and validated a scintigraphic test that evaluates reflux at both sites in patients at high risk of laryngopharyngeal reflux and lung aspiration. We hypothesized that the test may be able to separate physiologic reflux from pathological reflux and examined this possibility in normal asymptomatic volunteers. Asymptomatic volunteers were screened with the Belafsky reflux symptom index (RSI) and entered into the trial if scores were less than 13. 99m Tc Phytate was ingested orally and dynamic studies from the pharynx to the stomach were obtained while upright and supine. A delayed study of the thorax was also obtained for lung aspiration of refluxate. Studies were semi-quantitated graphically as time-activity curves. A total of 25 volunteers were studied (13 M, 12 F) with a mean age of 57.5 yr (Range 40-85 yr). None gave a history of heartburn or regurgitation. Mean RSI was 4.1 (range 0-10). Testing showed upright gastroesophageal reflux to the mid-upper esophagus without pharyngeal contamination in 32%. None of the subjects showed supine reflux or lung aspiration. This result corresponds well with intraluminal impedance/pH monitoring in normal volunteers. The scintigraphic reflux test gives similar results to standard intraluminal impedance/pH studies in normal volunteers. A significant proportion of asymptomatic volunteers demonstrate upright reflux only.
机译：胃食管反流疾病（GERD）是大多数西方国家的共同且不断增长的问题。它可能出现胃灼热症状和反流的典型症状或食管异味疾病的影响。我们已经开发并验证了闪烁的考验，评估患者在患者的患者中的回流，喉咽反流和肺吸入的高风险。我们假设测试可以能够将生理学回流与病理回流分离，并在正常无症状的志愿者中检查这种可能性。随着Belafsky回流症状指数（RSI）筛选无症状志愿者，如果分数小于13. 99M植物，则进入植物的口服，并在直立和仰卧的同时获得从植物对胃的动态研究。还可以获得对胸腔的延迟研究，用于回流酸盐的肺吸入。作为时间活性曲线将研究以图形方式半定量。研究了25名志愿者（13米，12°F），平均年龄为57.5 Yr（40-85岁范围）。没有给出胃灼热或反流的历史。平均RSI是4.1（范围0-10）。测试显示出直立的胃食管反流到中上部食道，没有咽部污染的32％。没有一个受试者显示出仰卧反流或肺吸入。该结果对应于普通志愿者中的腔内阻抗/ pH监测。闪烁的回流试验与正常志愿者的标准腔内阻抗/ pH研究相似。大量比例无症状志愿者仅展示了直立的回流。

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