...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Translational Research >Grainyhead-like 2 as a double-edged sword in development and cancer
【24h】

Grainyhead-like 2 as a double-edged sword in development and cancer

机译：麦芽平般的2作为一种正在开发和癌症的双刃剑

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Grainyhead-like 2 (GRHL2), one of the three homologs of Drosophila grainyhead, contributes to epithelial morphogenesis and differentiation. Dysregulation of GRHL2 has been shown to be involved in hearing loss and neural tube defects during embryogenesis. Moreover, it is well-recognized that GRHL2 suppresses epithelial-to-mesenchymal transition (EMT) that is required for migration and invasion of carcinoma, implicating, GRHL2 in carcinogenesis. Diverse mechanisms, as well as the varied roles of GRHL2 in different tumor tissues, have been elucidated. However, the functions of GRHL2 appear to be more complicated than initially thought. GRHL2, acting as either a tumor enhancer or a tumor inhibitor, depends on the type of cancer. In this review, we summarize research progress about normal physiological functions of GRHL2 including epithelial morphogenesis, neural tube closure, and hearing loss. Moreover, the mechanisms of GRHL2 in tumorigenesis, containing EMT suppression, forming a negative feedback loop with ZEB1 and miR200 family, interactions with estrogen receptor (ER)-dependent signaling pathway, regulation of telomerase reverse transcriptase and relationships with TGF-beta signaling pathway are discussed in this review in an effort to better understand the roles of GRHL2 in a variety of cancers toward the goal of GRHL2-targeted treatment in the near future.
机译：粒状黑麦般的2（GRHL2）是果蝇粒状头的三种同源物之一，有助于上皮形态发生和分化。已经显示GRHL2的失调参与胚胎发生期间的听力损失和神经管缺陷。此外，详细认识到，GRHL2抑制了迁移和侵袭癌的上皮 - 间充质转换（EMT），暗集癌症中的GRHL2。阐明了各种机制，以及GRHL2在不同肿瘤组织中的各种作用。然而，GRHL2的功能似乎比最初认为更复杂。 GRHL2，作为肿瘤增强剂或肿瘤抑制剂，取决于癌症的类型。在本综述中，我们总结了GRHL2正常生理功能的研究进展，包括上皮形态发生，神经管闭合和听力损失。此外，含有EMT抑制的GRHL2在肿瘤发生中的机制，形成具有ZEB1和MIR200家族的负反馈回路，与雌激素受体（ER） - 依赖性信号通路的相互作用，端粒酶逆转录酶的调节和与TGF-β信号传导途径的关系在本综述中讨论了，以更好地了解GRHL2在近期GRHL2目标治疗方面的GRHL2在各种癌症中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号