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首页> 外文期刊>International Journal of Electrochemical Science >Voltammetric Behavior of Trimetazidine Hydrochloride at Pre- anodized Carbon Paste Electrode and Its Determination in Pharmaceutical Formulations
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Voltammetric Behavior of Trimetazidine Hydrochloride at Pre- anodized Carbon Paste Electrode and Its Determination in Pharmaceutical Formulations

机译：在预阳极氧化碳浆料电极下盐酸盐酸盐的伏安行为及其在药物制剂中的测定

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摘要

A functional pre-anodized carbon paste electrode (PACPE) was prepared by 35 successive cycles of scans between 1.0V-1.8V in 0.2 mol L-1 NaOH solution. The electrode reaction mechanism of trimetazidine hydrochloride (TMZ) was carefully studied by CV method and was determined as a twoelectron/two-proton process, which is put forward for the first time. Experiment showed that the electrostatic attraction between the protonated TMZ and the negatively charged PACPE surface, both were affected by pH, was the dominant factor influencing the adsorption and the peak current. The PACPE exhibited excellent electrocatalytic effects towards the oxidation of TMZ. In the optimum conditions, the oxidation peak current was linear with TMZ concentration in the range of 5.0×10-7— 5.0×10-5 M (r=0.998), and the detection limit was estimated to be about 1.5×10-7 M. This method can be successfully applied to the determination of TMZ in pharmaceutical formulation.
机译：通过在0.2mol L-1 NaOH溶液中的1.0V-1.8V之间的35次扫描循环中制备官能预阳极氧化碳浆料电极（PACPE）。 通过CV方法仔细研究盐酸氮嗪（TMZ）的电极反应机制，并确定为双电器/两质子过程，首次提出。 实验表明，质子化TMZ与带负电荷的PACPE表面之间的静电吸引，两者都受到pH的影响，是影响吸附和峰值电流的显性因素。 PACPE对TMZ的氧化表现出优异的电催化作用。 在最佳条件下，氧化峰电流在5.0×10-7-5.0×10-5 m的范围内（r = 0.998），氧化峰电流是线性的，并且估计检测限估计为约1.5×10-7 M.该方法可以成功地应用于药物制剂中TMZ的测定。

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