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首页> 外文期刊>Frontiers in Public Health >Epidemiological Investigation and Virus Tracing of a Measles Outbreak in Zhoushan Islands, China, 2019
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Epidemiological Investigation and Virus Tracing of a Measles Outbreak in Zhoushan Islands, China, 2019

机译：舟山群岛，中国，2019年，麻疹爆发的流行病学调查与病毒追踪

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Background: Measles transmissions due to case importations challenge public health systems globally and herd immunities in all countries. In 2019, an imported measles case and its subsequently outbreak was found in the Zhoushan Islands. Here, the process of epidemiological investigation and virus tracing were summarized to provide references for the prevention and control of measles in the future. Materials and methods: The data on the demographic, epidemiological, and clinical manifestation of measles cases in this outbreak were collected. The 450 bp fragments of the measles virus (MeV) N gene were amplified and sequenced. The genome of the first imported case was further isolated. Then, the maximum-likelihood and time-scaled phylogenetic analysis was conducted. Results: A total of 28 measles cases were confirmed. Their onsets were between March 13 and May 18, 2019. The first patient was from the Ukraine. He was confirmed at the Fever Clinic in Zhoushan hospital on March 15, 2019 and at the same time, another patient had visited the hospital due to another illness and 10 days later, this second case had onset (March 25, 2019). The epidemic curve shows sustained community transmission. The majority of the following cases (19/26) were clustered on the Donggang street which was close to where the second case worked. The 22 measles virus strains successfully isolated from this outbreak all belonged to the D8.2a sub-cluster and clustered with the {"type":"entrez-nucleotide","attrs":{"text":"KY120864","term_id":"1115245600"}} KY120864 /MVs/GirSomnath.IND/42.16/[D8] which was the predominant genotype in the Ukraine during 2018-2019. The analysis of the complete D8 genotype genome pointed to the fact that this prevailing strain originated from India in 2015 and its substitution rate was estimated as 6.91 × 10 ?4 (5.64–7.98 × 10 ?4 ) nucleotide substitutions/site/year. Conclusion: This outbreak was caused by an imported case from the Ukraine. There was a possible nosocomial infection between the first case and the second case. Then, the second case played an important role in the spread of virus due to her occupation. The molecular phylogenetic analysis could help to track the origin of the virus. Increasing and maintaining the high level of vaccination coverage (≥95%) and an efficient response to imported cases are essential to prevent and control the recurrence and outbreak of measles virus.
机译：背景：麻疹传输由于案例进口挑战全球公共卫生系统和所有国家的畜群免疫力。 2019年，在舟山岛发现了进口麻疹案例及其随后的疫情。在这里，总结了流行病学调查和病毒追踪的过程，以提供对未来麻疹的预防和控制的参考。收集了材料和方法：收集了对麻疹在这种爆发中麻疹病例的人口统计学，流行病学和临床表现的数据。将450bp的麻疹病毒（MEV）N基因进行扩增并进行测序。进一步分离出第一进口案例的基因组。然后，进行最大似然和时间缩放的系统发育分析。结果：确认共28例麻疹病例。他们的持续网络是2019年3月13日至5月18日之间。第一员来自乌克兰。他于2019年3月15日在舟山医院发热诊所确认，同时，另一名患者由于另一种疾病而访问了该医院，10天后，第二案案件发病（2019年3月25日）。疫情曲线显示了持续的社区传播。以下大多数案件（19/26）集中在东港街上，靠近第二案件的工作。从这个爆发中成功孤立的22个麻疹病毒菌株都属于D8.2a子集群，并与{“类型”聚集在一起：“entrez-nucleotide”，“attrs”：{“text”：“ky120864”，“term_id” “：”1115245600“}} KY120864 / mVS/girsomnath.ind/42.16/ [D8]是2018 - 2019年乌克兰的主要基因型。完整的D8基因型基因组的分析指出的是，这一事实源于2015年印度的普遍应变及其替代率估计为6.91×10？4（5.64-7.98×10？4）核苷酸取代/遗址/年。结论：这种爆发是由乌克兰的进口案件引起的。第一种情况和第二种情况之间有可能的医院感染。然后，第二种病例在病毒引起的扩散中起重要作用。分子系统的分析可以有助于跟踪病毒的起源。增加和维持高水平的疫苗接种覆盖率（≥95％）和对进口病例的有效反应对于预防和控制麻疹病毒的复发和爆发至关重要。

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