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首页> 外文期刊>Frontiers in Public Health >Two Cases of Influenza B Virus-Related Fatal Fulminant Pneumonia Complicated With Staphylococcus aureus Infection in China Diagnosed Using Next-Generation Sequencing (2018)
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Two Cases of Influenza B Virus-Related Fatal Fulminant Pneumonia Complicated With Staphylococcus aureus Infection in China Diagnosed Using Next-Generation Sequencing (2018)

机译：甲型流感病毒相关致命漏血肺炎的两种患者在中国诊断出中国金黄色葡萄球菌感染（2018）

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摘要

Two rare cases of Chinese female patients with influenza B virus infection complicated with both fulminant pneumonia and septicemia caused by Panton–Valentine leukocidin(PVL) positive methicillin-sensitive Staphylococcus aureus (MASS) were reported for the first time in China through next-generation sequencing (NGS). An increasing body of evidence indicates that co-infection with influenza B virus and bacterial pneumonia is often fatal. Rapid and precise identification of the co-infection bacteria can guide the selection of treatment for patients with influenza virus infection in the clinical setting. In this study, next-generation sequencing (NGS) was applied for the rapid diagnosis of these two cases. Despite the unfavorable survival outcome of these patients, the application of next-generation sequencing showed promise as a diagnostic tool for the rapid diagnosis of unknown pathogens in patients with bacterial pneumonia and sepsis. This method can guide the administration of medications in such patients.
机译：两次含有膨胀性肺炎（PVL）阳性甲虫敏感葡萄球菌（质量）的膨胀性肺炎（PV1）阳性甲氧西林敏感金黄色葡萄球菌（质量）的两种雌激素肺炎病毒感染病例（ngs）。越来越多的证据表明，对流感B病毒和细菌肺炎的共感染往往是致命的。快速和精确的共感染细菌鉴定可以指导临床环境中患有流感病毒感染患者的治疗。在该研究中，应用下一代测序（NGS）在这两种情况下迅速诊断。尽管这些患者的存活率不利，但下一代测序的应用显示了许可作为患有细菌肺炎和败血症患者未知病原体的诊断工具。该方法可以指导这些患者的药物施用。

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