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首页> 外文期刊>Open Journal of Ophthalmology >Does Anti-Vascular Endothelial Growth Factor Treatment Delay Photoreceptor Maturation in Preterm Infants?
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Does Anti-Vascular Endothelial Growth Factor Treatment Delay Photoreceptor Maturation in Preterm Infants?

机译：抗血管内皮生长因子治疗延迟光感受器成熟在早产儿吗？

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P urpose: To investigate the effects ofintravitreal anti-vascular endothelial growth factor (VEGF) for treatment of type-1 or aggressive posteriorretinopathy of prematurity (ROP) on photoreceptor maturation in preterm infantsusing spectral domain optical coherencetomography (SD-OCT). Methods: A study group of 36 patients with ROPtreated with anti-VEGF therapy was compared to a control group of 80 patientswith ROP. All patients had undergone SD-OCT imaging at least once between 40 and 44 weekspost-menstrual age (PMA). Two imagingspecialists evaluated the images for ellipsoid zone (EZ) development, cystoidmacular edema (CME), sub-retinal fluid (SRF) at the fovea, and cone outersegment tips (COST). The outer nuclear layer thickness and the distance fromthe EZ to the central fovea was measured. Results: EZ development wasobserved in 18 (50%) patients in the study group and 68 (85%) in the controlgroup (p = 0.002). CME was observed in 17 (47.2%) patients in the study groupand 17 (21.2%) in the control group. The distance between the EZ and centralfovea was 868 ± 440 μm in the study group and 725 ± 380 μm in the control group(p = 0.02). COST was not observed in any patient. Regression analysis indicatedthat anti-VEGF treatment and CME affect EZ development. Conclusions: Early photoreceptor maturation is correlated with preterm birth week but not ROP stage. Anti-VEGF treatment delaysphotoreceptor maturation in preterm infants.
机译：p furpume：探讨intravitaveal抗血管内皮生长因子（VEGF）治疗早熟（ROP）型或侵蚀性后虫病的影响，在早产儿发育型光谱域光学组织术（SD-OCT）中的感光体成熟的1型或侵蚀性后虫病。 方法：将36例抗VEGF治疗患者的研究组与80例患者的对照组进行比较。所有患者均未在40至44周前期（PMA）之间的SD-OCT成像至少一次。两位图像专业家评估了椭球区域（EZ）发育，囊体脉动水肿（CME），亚视液（SRF），锥形外精会（成本）的图像。测量外部核层厚度和距离EZ至中央FOVEA的距离。 结果：在研究组的18名（50％）患者中，ez开发患者，对照组68（85％）（p = 0.002）。在对照组的研究Groupand 17（21.2％）中，在17例（47.2％）患者中观察到CME。研究组EZ和Centralfovea之间的距离为868±440μm，对照组725±380μm（p = 0.02）。任何患者都没有观察到成本。回归分析表明，抗VEGF治疗和CME影响EZ发育。 结论：早期光感受器成熟与早产出生周相关但不是ROP阶段。抗VEGF治疗会延迟早产儿的运动患者成熟。

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