...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Open Journal of Respiratory Diseases >Expiratory Flow Limitation and Its Relation to Dyspnea and Lung Hyperinflation in Patients with Chronic Obstructive Pulmonary Disease: Analysis Using the Forced Expiratory Flow-Volume Curve and Critique
【24h】

Expiratory Flow Limitation and Its Relation to Dyspnea and Lung Hyperinflation in Patients with Chronic Obstructive Pulmonary Disease: Analysis Using the Forced Expiratory Flow-Volume Curve and Critique

机译：呼气流动限制及其与慢性阻塞性肺病患者呼吸困难和肺过度血液的关系：使用迫使呼气流量曲线和批判分析

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Tidal expiratory flow limitation (tEFL) is defined as absence of increase in air flow during forced expiration compared to tidal breathing and is related to dyspnea at rest and minimal exertion in patients with chronic airflow limitation (CAL). Tidal EFL has not been expressed as a continuous variable (0% - 100%) in previous analyses. Objective: To relate the magnitude of tEFL to spirometric values and Modified Medical Research Council (MMRC) score and Asthma Control Test (ACT). Methods: Tidal EFL was computed as percent of the tidal volume (0% - 100%) spanned (intersected) by the forced expiratory-volume curve. Results: Of 353 patients screened, 192 (114 M, 78 F) patients (136 with COPD, 56 with asthma) had CAL. Overall characteristics: (mean ± SD) age 59 ± 11 years, BMI 28 ± 7, FVC (% pred) 85 ± 20, FEV1 (% pred) 66 ± 21, FEV1/FVC 55% ± 10%, RV (% pred) 147 ± 42. Tidal EFL in patients with tEFL was 53% ± 39%. Using univariate analysis, strongest correlations were between tEFL and FVC and between tEFL and RV in patients with BMI < 30 kg/m ~( 2 ) . In patients with nonreversible CAL, tEFL was positively associated with increasing MMRC, negatively with spirometric measurements, and positively with RV/TLC. In asthmatics, ACT scores were higher in patients with mean BMI ≥ 28 kg/m ~( 2 ) (p < 0.00014) and RV/TLC values > 40% (p < 0.03). Conclusions: Dyspnea is strongly associated with tEFL and lung function, particularly in patients with nonreversible CAL. Air trapping and BMI contribute to tEFL.
机译：背景：与潮气呼吸相比，潮汐呼气流动限制（TIF1）定义为强制呼吸期间空气流量的增加，并且与慢性气流限制（CAL）患者的休息和最小的努力有关的呼吸困难。潮汐EFL尚未以先前的分析表达为连续变量（0％ - 100％）。 目的：将TEFL的大小与肺活量计值和修改后的医学研究委员会（MMRC）评分和哮喘控制试验相关联（ACT）。 方法：通过强制呼气量曲线计算潮汐efl为潮气量（0％ - 100％）的百分比百分比。 结果：353例患者筛选，192例（114米，78°F）患者（带有COPD，56名带有哮喘）的患者。总体特征：（平均值±SD）年龄59±11岁，BMI 28±7，FVC（％pred）85±20，FEV1（％pred）66±21，FEV1 / FVC 55％±10％，RV（％pred％ ）147±42. TIDAL EFL中的TIDAL EFL患者为53％±39％。使用单变量分析，TEFL和FVC之间的最强相关性以及BMI <30kg / m〜（2）患者的TEFL和RV之间。在不可抗拒Cal的患者中，TEF1与增加MMRC呈正相关，对肌肉测量测量呈负面影响，以及与RV / TLC正面。在哮喘学中，平均BMI≥28kg/ m〜（2）（P <0.00014）和RV / TLC值> 40％（P <0.03），患者的行为评分较高。 结论：呼吸困难与TEFL和肺功能强烈有关，特别是在不可转让的CAL患者中。空气俘获和BMI有助于TEFL。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号