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首页> 外文期刊>Orthopaedic Journal of Sports Medicine >Efficacy of Intraoperative Platelet-Rich Plasma Augmentation and Postoperative Platelet-Rich Plasma Booster Injection for Rotator Cuff Healing: A Randomized Controlled Clinical Trial
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Efficacy of Intraoperative Platelet-Rich Plasma Augmentation and Postoperative Platelet-Rich Plasma Booster Injection for Rotator Cuff Healing: A Randomized Controlled Clinical Trial

机译：富含血小板富含血浆增强和术后富含血小板的血浆增压器注射术治疗术争的疗效：随机对照临床试验

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Background: Platelet-rich plasma (PRP) has been applied as an adjuvant treatment for arthroscopic rotator cuff repair (ARCR) to enhance rotator cuff healing. However, it remains debatable whether PRP enhances tendon-to-bone healing. Purpose: To assess the efficacy of intraoperative augmentation and postoperative injection of PRP that was prepared using the double-spin method and calcium activation without thrombin in patients with ARCR. Study Design: Randomized controlled trial; Level of evidence, 1; and cohort study; Level of evidence, 3. Methods: A total of 58 patients underwent ARCR using intraoperative PRP augmentation. Half of the patients were randomly assigned to receive an additional ultrasound-guided PRP injection at the repair site at 2 weeks postoperatively (PRP-booster group); the other half did not receive the booster injection (PRP-only group). A control group that did not receive any PRP treatment was retrospectively matched using propensity score matching. Structural integrity was assessed using magnetic resonance imaging at 1 year postoperatively, and healing rates were compared between patients with tear sizes ≤2 cm versus &2 cm. Functional outcomes were assessed using the visual analog scale (VAS) for pain; VAS for satisfaction; shoulder range of motion; and Constant, American Shoulder and Elbow Surgeons, and Simple Shoulder Test scores at minimum 2-year follow-up. Results: In patients with tears &2 cm, the rate of healing failure at 1-year follow-up was significantly less in the overall PRP group than in the control group (12.9% vs 35.7%, respectively; P = .040), however, the PRP-booster group did not present a better healing rate than did the PRP-only group. The overall PRP group had lower VAS for pain scores compared with the control group (0.5 ± 1.1 vs 1.3 ± 1.8, respectively; P = .016) and higher VAS for satisfaction scores (9.2 ± 1.2 vs 8.6 ± 1.7; P = .023) at the final follow-up, whereas no statistical difference was found between the PRP-only and PRP-booster groups in functional outcomes. Conclusion: Intraoperative PRP augmentation during ARCR demonstrated superior anatomic healing results in patients with rotator cuff tears &2 cm as well as reduced pain and increased subjective satisfaction. PRP booster injection provided no additional benefit to tendon integrity or functional recovery.
机译：背景：富含血小板的血浆（PRP）已被应用于关节镜旋转器袖带修复（ARCR）的佐剂处理，以增强旋转箍愈合。然而，PRP是否增强肌腱对骨愈合仍然有疑惑。目的：评估术中增强和术后注射PRP的疗效，所述PRP在患有ARCR的患者中使用双旋转方法和钙活化而没有凝血酶制备的。研究设计：随机对照试验;证据水平，1;和队列研究;证据水平，3.方法：使用术中PRP增强共有58例患者进行ARCR。一半的患者被随机分配，在术后2周（Prp-Booster Group）在修复部位接受额外的超声引导PRP注射;另一半没有收到增强剂（仅限PRP组）。无回顾任何PRP处理的对照组使用倾向得分匹配来回顾性地匹配。使用磁共振成像在术后1年来评估结构完整性，并在撕裂尺寸≤2cm与amp的患者之间进行愈合率; 2cm。使用视觉模拟量表（VAS）进行疼痛评估功能结果;满意度;肩部运动范围;和恒定，美国肩部和肘部外科医生，以及至少2年后的简单的肩部测试分数。结果：在泪液＆amp; 2厘米的患者中，总PRP组在1年后的愈合失败率明显少于对照组（分别为12.9％Vs 35.7％; P =。然而，040）然而，PRP-Booster基团没有比PRP-ops群体更好地呈现更好的愈合率。与对照组相比，总体PRP组的VAS疼痛评分（分别为0.5±1.1±1.3±1.8，分别为0.5±1.1±1.3±1.8）和较高的vas以获得满意度分数（9.2±1.2与8.6±1.7; p = .023 ）在最终的随访中，在功能结果中，PrP-oild和Prp-Booster组之间没有发现统计差异。结论：ARCR期间的术中PRP增强表现出旋转袖口撕裂患者的优异解剖学愈合结果＆amp; 2厘米，减少疼痛和提高主观满意度。 PRP增强剂注入不提供肌腱完整性或功能恢复的额外益处。

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