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首页> 外文期刊>The Journal of automatic chemistry >Liquiritin from Radix Glycyrrhizae Protects Cardiac Mitochondria from Hypoxia/Reoxygenation Damage
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Liquiritin from Radix Glycyrrhizae Protects Cardiac Mitochondria from Hypoxia/Reoxygenation Damage

机译：来自γ甘草的液体素免受缺氧/雷诺损伤的心脏线粒体

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Aims The purpose of this study was to evaluate the protective effect of liquiritin (LIQ) from Radix Glycyrrhizae on cardiac mitochondria against hypoxia/reoxygenation (HR) injury. Methods H9C2 cells were subject to the HR model. LIQ purified from Radix Glycyrrhizae (purity?>?95%) was administrated to reoxygenation period. Cell viability, mitochondrial mass, mitochondrial membrane potential, reactive oxygen species, and mitochondrial Ca~(2)? level were then assessed by using Cell Counting kit-8 and suitable fluorescence probe kits. Results LIQ administration remarkably reduced the rate of HR damage via increasing H9C2 cell viability level and preserving mitochondria after HR. Particularly, 60? μ M of LIQ posthypoxic treatment markedly reduced cell death in HR-subjected H9C2 cell groups ( p < 0.05). Interestingly, posthypoxic treatment of LIQ significantly prevented the loss of mitochondrial membrane potential, the decrease in mitochondrial mass, the increase in reactive oxygen species production, and the elevation of mitochondrial Ca~(2)? level in HR-treated H9C2 cells. Conclusion The present study provides for the first time the cardioprotective of LIQ posthypoxic treatment via reducing H9C2 cell death and protecting cardiac mitochondria against HR damage.
机译：目的是本研究的目的是评估Liquiritin（Liq）从糖尿基粒细胞对缺氧/雷诺（HR）损伤的心脏线粒体的保护作用。方法H9C2细胞受HR模型。 Liq纯化从甘草甘草（纯度？>？> 95％）被施用于雷诺治疗期。细胞活力，线粒体质量，线粒体膜电位，反应性氧物种和线粒体Ca〜（2）？然后通过使用细胞计数试剂盒和合适的荧光探针试剂盒来评估水平。结果LIQ管理通过增加H9C2细胞活力水平并在HR后保持线粒体损伤，显着降低了HR损伤的速率。特别是60？ μMLiq Posyypoxic治疗在HR受试H9C2细胞基团中显着降低了细胞死亡（P <0.05）。有趣的是，LIQ的碱基毒性治疗显着防止了线粒体膜电位的丧失，线粒体质量的降低，反应性氧物种的增加，和线粒体Ca的升高〜（2）？在HR处理的H9C2细胞中水平。结论本研究首次通过减少H9C2细胞死亡和保护心肌细胞免受人力资源损伤的第一次对LIQ痘痘治疗的心脏保护性进行。

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