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首页> 外文期刊>The Journal of automatic chemistry >Quality Evaluation of Artemisia capillaris Thunb. Based on Qualitative Analysis of the HPLC Fingerprint and UFLC-Q-TOF-MS/MS Combined with Quantitative Analysis of Multicomponents
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Quality Evaluation of Artemisia capillaris Thunb. Based on Qualitative Analysis of the HPLC Fingerprint and UFLC-Q-TOF-MS/MS Combined with Quantitative Analysis of Multicomponents

机译：蒿属植物辣椒的质量评价。 基于HPLC指纹和UFLC-Q-TOF-MS / MS的定性分析结合多组分的定量分析

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摘要

In this study, a new method was developed for the comprehensive quality evaluation (QE) of Artemisia capillaris Thunb. ( A. capillaris , named Yinchenhao in Chinese), which is one of the most commonly used herbal medicines (HMs). First, fingerprints of 31 batch samples of A. capillaris were determined by HPLC, the reference fingerprint was established, and the common peaks were assigned. Second, the components of common peaks in the HPLC fingerprints were identified by ultrafast liquid chromatography- (UFLC-) Q-TOF-MS/MS. Finally, the contents of the components unambiguously confirmed by reference substances were determined, and the correlation between the contents of chlorogenic acid and the contents of others was analyzed. The results showed that there were 20 common peaks in the HPLC fingerprints of 31 batch samples. The components of these 20 common peaks were identified as ten organic acids, eight flavonoids, and two others. Among nine organic acids such as 1-caffeoylquinic acid, neochlorogenic acid, chlorogenic acid, caffeic acid, cryptochlorogenic acid, 1,3-dicaffeoylquinic acid, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, and 4,5-dicaffeoylquinic acid, three flavonoids such as rutin, hyperoside, and isoquercetin, and one other p -hydroxyacetophenone, a total of 13 ones were unambiguously identified by comparison with reference substances; one caffeoylquinic acid glucoside and one flavone di-C-glucoside were detected in A. capillaris for the first time. There were some differences in the contents of 13 components in different samples; chlorogenic acid could be regarded as the quality marker of A. capillaris . The current established method in this study can be used for the comprehensive QE of A. capillaris and can also provide reference for the QE of the other HMs.
机译：在这项研究中，开发了一种新的方法，用于蒿属植物辣椒的综合质量评价（QE）。 （A. Capillaris，名为Yinchenhao的中文），这是最常用的草药（HMS）之一。首先，通过HPLC测定31个批次样品的指纹样品，建立了参考指纹，分配了常见的峰。其次，通过超快液相色谱 - （UFLC-）Q-TOF-MS / MS鉴定HPLC指纹中常见峰的组分。最后，确定了通过参考物质明确证实的组分的内容物，分析了绿原酸含量与其他物质内容物之间的相关性。结果表明，31个分批样品的HPLC指纹中有20个常见峰。将这20个常见峰的组分鉴定为10个有机酸，八种类黄酮和另外两种。在九个有机酸中，例如1-咖啡算法，新泛酸，绿原酸，咖啡酸，粘酰基氯酸，1,3-二氧化酰酸，3,4-二氧化酰基丙酸，3,5-二咖啡胂酸和4,5-二聚咖啡酸酸，三种类黄酮，如芦丁，高血清苷和异喹啉，以及另一种对p-羟基乙酮，通过与参考物质进行比较明确鉴定13个;首次在A. Capillaris中检测到一种咖啡酸氨基酸葡萄糖苷和一种黄酮二-C-葡糖苷。不同样本中的13个组分的内容差异存在一些差异;绿原酸可被视为毛细血管的质量标志物。本研究中的现状的现已建立的方法可用于A. Capillaris的综合QE，也可以为其他HMS的QE提供参考。

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