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首页> 外文期刊>Journal of Diabetes Science and Technology >Evaluation of Opportunities and Limitations of Mid-Infrared Skin Spectroscopy for Noninvasive Blood Glucose Monitoring
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Evaluation of Opportunities and Limitations of Mid-Infrared Skin Spectroscopy for Noninvasive Blood Glucose Monitoring

机译：非血糖血糖监测中红外皮肤光谱的机会和限制评价

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Background: A wide range of optical techniques has recently been presented for the development of noninvasive methods for blood glucose sensing based on multivariate skin spectrum analysis, and most recent studies are reviewed in short by us. The vibrational spectral fingerprints of glucose, as especially found in the mid-infrared or Raman spectrum, have been suggested for achieving largest selectivity for the development of noninvasive blood glucose methods. Methods: Here, the different aspects on integral skin measurements are presented, which are much dependent on the absorption characteristics of water as the main skin constituent. In particular, different mid-infrared measurement techniques as realized recently are discussed. The limitations of the use of the attenuated total reflection technique in particular are elaborated, and confounding skin or saliva spectral features are illustrated and discussed in the light of recently published works, claiming that the attenuated total reflection technique can be utilized for noninvasive measurements. Results: It will be shown that the penetration depth of the infrared radiation with wavelengths around 10?μm is the essential parameter, which can be modulated by different measurement techniques as with photothermal or diffuse reflection. However, the law of physics is limiting the option of using the attenuated total reflection technique with waveguides from diamond or similar optical materials. Conclusions: There are confounding features from mucosa, stratum corneum , or saliva, which have been misinterpreted for glucose measurements. Results of an earlier study with multivariate evaluation based on glucose fingerprint features are again referred to as a negative experimental proof.
机译：背景：最近已经提出了广泛的光学技术，用于基于多变量皮肤谱分析的血糖感测的非血糖方法的开发，最近的研究简而言之，我们综述了。已经提出了在中红外或拉曼光谱中特别发现的葡萄糖的振动光谱指纹，以实现对非血糖血糖方法的发展最大的选择性。方法：在此，提出了整体皮肤测量的不同方面，这很大程度上取决于水作为主要皮肤成分的吸收特性。特别地，讨论了最近实现的不同中红外测量技术。特别是阐述了衰减总反射技术的局限性被阐述，并且根据最近公开的作品说明并讨论了混杂的皮肤或唾液谱特征，声称可以使用减毒的总反射技术来用于非侵入性测量。结果：将表明，红外辐射的穿透深度约为10Ωμm是基本参数，其可以通过与光热或漫射反射的不同测量技术来调制。然而，物理定律限制了使用来自金刚石或类似光学材料的波导的衰减全反射技术的选择。结论：粘膜，角质层或唾液中存在混杂特征，这些特征被误解为葡萄糖测量。基于葡萄糖指纹特征的多变量评估的早期研究结果再次被称为负实验证据。

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