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首页> 外文期刊>Journal of International Medical Research >Human papillomavirus DNA and p16 expression in head and neck squamous cell carcinoma in young French patients
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Human papillomavirus DNA and p16 expression in head and neck squamous cell carcinoma in young French patients

机译：人类乳头瘤病毒DNA和P16在颈部鳞状细胞癌中的幼年患者

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Objectives Human papillomavirus (HPV) is a risk factor for head and neck squamous cell carcinoma (HNSCC), which is currently increasing worldwide. We evaluated the prevalence of HPV DNA and p16 expression in HNSCC patients age &45 years compared with patients aged ≥45 years. Methods Thirty-nine patients aged &45 years who presented at Besan?on University Hospital with HNSCC since 2005 were included in this retrospective study. HPV DNA was detected by HPV genotyping and p16 expression was determined by immunohistochemistry using paraffin-embedded tissues. A matched-group of 38 patients aged ≥45 years from Besan?on University Hospital was included. Results The overall prevalence of HPV infection was 11.7%. HPV16 was the only genotype detected in 4/39 and 5/38 patients, and p16 was expressed in 6/39 and 4/38 patients aged &45 years and ≥45 years, respectively. Conclusions HPV-positivity and p16 expression were similar in both age groups. The results suggest that p16 immunohistochemistry may provide a prognosis biomarker for all HNSCCs, not only oropharyngeal cancers, and this should be addressed in large clinical trials.
机译：目的人乳头瘤病毒（HPV）是头部和颈部鳞状细胞癌（HNSCC）的危险因素，目前正在全球范围内增加。我们评估了HPV DNA和P16表达在HNSCC患者年龄＆amp中的患病率。与≥45岁的患者相比，45岁。方法三十九名患者年龄较大的患者＆amp; LT; 45岁介绍在BENAN？自2005年以来，在此回顾性研究中纳入HNSCC的大学医院。通过HPV基因分型检测HPV DNA，通过使用石蜡包埋的组织通过免疫组织化学测定P16表达。距离Besan≥45岁的38名患者的匹配组？在大学医院被包括在内。结果HPV感染的总体流行率为11.7％。 HPV16是4/39和5/38患者唯一检测到的基因型，P16在6/39和4/38患者中表达，分别为45岁和≥45岁。结论HPV-阳性和P16表达在两个年龄组中相似。结果表明，P16免疫组织化学可为所有HNSCCS提供预后生物标志物，不仅是口咽癌症的，而且应该在大型临床试验中解决这一点。

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