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首页> 外文期刊>Journal of International Medical Research >Embryonic cervical rhabdomyosarcoma complicated with uterine inversion with cerebral venous sinus thrombosis as the first symptom: a case report and literature review
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Embryonic cervical rhabdomyosarcoma complicated with uterine inversion with cerebral venous sinus thrombosis as the first symptom: a case report and literature review

机译：胚胎宫颈骨髓瘤和子宫静脉血栓血栓血栓血栓形成为第一个症状：一个案例报告和文献综述

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摘要

The probability of rhabdomyosarcoma occurring in the cervix is less than 0.5% and may be associated with a pathogenic dicer 1, ribonuclease III ( DICER1 ) gene variation. Tumour-induced hypercoagulability and high levels of cancer antigen (CA) 125 are risk factors for cerebral venous sinus thrombosis (CVST). In addition, although nonpuerperal uterine inversion is very rare and is usually caused by leiomyomas from the uterus, large cervical masses can also be the cause. This case report describes a 24-year-old woman with uterine inversion caused by an embryonic cervical rhabdomyosarcoma that presented with CVST as her first symptom. The patient underwent laparoscopic total uterus and bilateral salpingectomy, during which the uterus was found to be completely inverted. Postoperative pathology confirmed embryonic cervical rhabdomyosarcoma. The patient quickly developed lung and para-aortic lymph node metastases. Two months later, the patient died of complications. When coagulation indices in patients with tumours are abnormal, especially when the levels of D-dimer and CA125 increase, it is recommended that anticoagulant therapy is administered in a timely manner to prevent the occurrence of CVST. Furthermore, for large cervical tumours, physicians should also be alert to the occurrence of uterine inversion.
机译：在子宫颈中发生的横纹肌肉瘤的概率小于0.5％，并且可以与致病剂1，核糖核酸酶III（Dicer1）基因变异相关。肿瘤诱导的高凝血性和高水平的癌症抗原（CA）125是脑静脉血栓血栓形成（CVST）的危险因素。此外，虽然非屈服子宫倒置是非常罕见的，但通常由子宫内霉菌引起，但大宫颈肿块也可以是原因。本案例报告描述了一名24岁女性，具有由胚胎颈椎骨髓瘤引起的子宫倒置，其作为她的第一个症状呈现CVST。患者接受了腹腔镜的总子宫和双侧Salpectomy，在此期间发现子宫被完全倒置。术后病理学确认了胚胎颈椎肿瘤瘤。患者迅速开发肺和副主动脉淋巴结转移。两个月后，患者死于并发症。当肿瘤患者的凝血指数异常时，特别是当D-二聚体和CA125的水平增加时，建议以及时施用抗凝治疗以防止发生CVST的发生。此外，对于大型宫颈肿瘤，医生也应该警惕子宫反转的发生。

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