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首页> 外文期刊>Applied Microbiology >Prevalence of Potentially Pathogenic Antibiotic-Resistant Aeromonas spp. in Treated Urban Wastewater Effluents versus Recipient Riverine Populations: a 3-Year Comparative Study
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Prevalence of Potentially Pathogenic Antibiotic-Resistant Aeromonas spp. in Treated Urban Wastewater Effluents versus Recipient Riverine Populations: a 3-Year Comparative Study

机译：潜在致病抗生素抗性航空SPP的患病率。 在经过治疗的城市废水污水与受援者河流人口（3年的比较研究）

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Antibiotic resistance continues to be an emerging threat both in clinical and environmental settings. Among the many causes, the impact of postchlorinated human wastewater on antibiotic resistance has not been well studied. Our study compared antibiotic susceptibility among Aeromonas spp. in postchlorinated effluents to that of the recipient riverine populations for three consecutive years against 12 antibiotics. Aeromonas veronii and Aeromonas hydrophila predominated among both aquatic environments, although greater species diversity was evident in treated wastewater. Overall, treated wastewater contained a higher prevalence of nalidixic acid-, trimethoprim-sulfamethoxazole (SXT)-, and tetracycline-resistant isolates, as well as multidrug-resistant (MDR) isolates compared to upstream surface water. After selecting for tetracycline-resistant strains, 34.8% of wastewater isolates compared to 8.3% of surface water isolates were multidrug resistant, with nalidixic acid, streptomycin, and SXT being the most common. Among tetracycline-resistant isolates, efflux pump genes tetE and tetA were the most prevalent, though stronger resistance correlated with tetA. Over 50% of river and treated wastewater isolates exhibited cytotoxicity that was significantly correlated with serine protease activity, suggesting many MDR strains from effluent have the potential to be pathogenic. These findings highlight that conventionally treated wastewater remains a reservoir of resistant, potentially pathogenic bacterial populations being introduced into aquatic systems that could pose a threat to both the environment and public health.IMPORTANCE Aeromonads are Gram-negative, asporogenous rod-shaped bacteria that are autochthonous in fresh and brackish waters. Their pathogenic nature in poikilotherms and mammals, including humans, pose serious environmental and public health concerns especially with rising levels of antibiotic resistance. Wastewater treatment facilities serve as major reservoirs for the dissemination of antibiotic resistance genes (ARGs) and resistant bacterial populations and are, thus, a potential major contributor to resistant populations in aquatic ecosystems. However, few longitudinal studies exist analyzing resistance among human wastewater effluents and their recipient aquatic environments. In this study, considering their ubiquitous nature in aquatic environments, we used Aeromonas spp. as bacterial indicators of environmental antimicrobial resistance, comparing it to that in postchlorinated wastewater effluents over 3 years. Furthermore, we assessed the potential of these resistant populations to be pathogenic, thus elaborating on their potential public health threat.
机译：抗生素抗性在临床和环境环境中仍然是一种新兴威胁。在许多原因中，脱白氯化的人废水对抗生素抗性的影响并未得到很好的研究。我们的研究比较了Aeromonas SPP之间的抗生素敏感性。在脱氯流出的污水中连续三年与12次抗生素一起进行。 Aeromonas Veronii和Aeromonas疏水层在水生环境中占主导地位，尽管在经过处理过的废水中可以显而易见。总体而言，经过处理的废水含有较高的萘啶酸 - ，三甲双胍 - 磺胺甲恶唑（SXT） - 和四环素抗性分离物，以及与上游地表水相比的多药（MDR）分离物。选择四环素抗性菌株后，34.8％的废水分离物与8.3％的表面水分离株相比是多药物抗性的，用萘啶酸，链霉素和SXT是最常见的。在四环素抗性分离物中，流出泵基因Tete和Teta是最普遍的，尽管与Teta相关的耐抗性较强。超过50％的河流和经过治疗的废水分离株表现出与丝氨酸蛋白酶活性显着相关的细胞毒性，表明许多来自流出物的MDR菌株具有致病性。这些发现强调，常规处理的废水仍然是抗性的储层，潜在的致病细菌群体被引入到可能对环境和公共卫生造成威胁的水生体系中。动机是革兰阴性的，是自同的革兰根的革兰阴性，生殖棒状细菌在新鲜和咸水的水域中。他们在Poikilothothotherms和哺乳动物中的致病性质，包括人类，构成严重的环境和公共卫生的担忧，尤其是抗生素抗性水平上升。污水处理设施作为传播抗生素抗性基因（ARGS）和抗性细菌种群的主要水库，因此是水生生态系统中抗性群体的潜在主要因素。然而，很少有纵向研究存在分析人废水污水及其受体水产环境之间的抗性。在这项研究中，考虑到水生环境中的无处不在的性质，我们使用了Aeromonas SPP。作为环境抗微生物抗性的细菌指标，将其与3年以上的白氯废水流出物进行比较。此外，我们评估了这些抗性群体的潜力是致病性的，因此阐述了他们潜在的公共卫生威胁。

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