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首页> 外文期刊>Applied Microbiology >Predatory Organisms with Untapped Biosynthetic Potential: Descriptions of Novel Corallococcus Species C. aberystwythensis sp. nov., C. carmarthensis sp. nov., C. exercitus sp. nov., C. interemptor sp. nov., C. llansteffanensis sp. nov., C. praedator sp. nov., C. sicarius sp. nov., and C. terminator sp. nov.
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Predatory Organisms with Untapped Biosynthetic Potential: Descriptions of Novel Corallococcus Species C. aberystwythensis sp. nov., C. carmarthensis sp. nov., C. exercitus sp. nov., C. interemptor sp. nov., C. llansteffanensis sp. nov., C. praedator sp. nov., C. sicarius sp. nov., and C. terminator sp. nov.

机译：具有未开发的生物合成潜在描述的捕食性生物，新型CoraloCoccus C. Aberystwthensis SP。 11月，C. carmarthensis sp。 11月。，C.陆军SP。 11月，C.Pintpentor SP。 11月。，C.Llansistefanansis SP。 11月。，C.掠夺SP。 11月，C. assasninum sp。 11月。，C.终结者SP。 11月。

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Corallococcus spp. are common soil-dwelling organisms which kill and consume prey microbes through the secretion of antimicrobial substances. Two species of Corallococcus have been described previously ( Corallococcus coralloides and Corallococcus exiguus ). A polyphasic approach, including biochemical analysis of fatty acid methyl esters, substrate utilization, and sugar assimilation assays, was taken to characterize eight Corallococcus species strains and the two type strains. The genomes of all strains, including that of C. exiguus DSM 14696~(T) (newly reported here), shared an average nucleotide identity below 95% and digital DNA-DNA hybridization scores of less than 70%, indicating that they belong to distinct species. In addition, we characterized the prey range and antibiotic resistance profile of each strain, illustrating the diversity of antimicrobial activity and, thus, the potential for drug discovery within the Corallococcus genus. Each strain gave a distinct profile of properties, which together with their genomic differences supports the proposal of the eight candidate strains as novel species. The eight candidates are as follows: Corallococcus exercitus sp. nov. (AB043A~(T) = DSM 108849~(T) = NBRC 113887~(T)), Corallococcus interemptor sp. nov. (AB047A~(T) = DSM 108843~(T) = NBRC 113888~(T)), Corallococcus aberystwythensis sp. nov. (AB050A~(T) = DSM 108846~(T) = NBRC 114019~(T)), Corallococcus praedator sp. nov. (CA031B~(T) = DSM 108841~(T) = NBRC 113889~(T)), Corallococcus sicarius sp. nov. (CA040B~(T) = DSM 108850~(T) = NBRC 113890~(T)), Corallococcus carmarthensis sp. nov. (CA043D~(T) = DSM 108842~(T) = NBRC 113891~(T)), Corallococcus llansteffanensis sp. nov. (CA051B~(T) = DSM 108844~(T) = NBRC 114100~(T)), and Corallococcus terminator sp. nov. (CA054A~(T) = DSM 108848~(T) = NBRC 113892~(T)).IMPORTANCE Corallococcus is a genus of predators with broad prey ranges, whose genomes contain large numbers of gene clusters for secondary metabolite biosynthesis. The physiology and evolutionary heritage of eight Corallococcus species strains were characterized using a range of analyses and assays. Multiple metrics confirmed that each strain belonged to a novel species within the Corallococcus genus. The strains exhibited distinct patterns of drug resistance and predatory activity, which mirrored their possession of diverse sets of biosynthetic genes. The breadth of antimicrobial activities observed within the Corallococcus genus highlights their potential for drug discovery and suggests a previous underestimation of both their taxonomic diversity and biotechnological potential. Taxonomic assignment of environmental isolates to novel species allows us to begin to characterize the diversity and evolution of members of this bacterial genus with potential biotechnological importance, guiding future bioprospecting efforts for novel biologically active metabolites and antimicrobials.
机译：Corallococcus spp。是常见的土壤住宅生物，通过分泌抗微生物物质杀死和消耗猎物微生物。之前（Corallococcus Coralloides和Corallococcus Exiguus）已经描述了两种Coralloccus。采用多相方法，包括脂肪酸甲酯，衬底利用和糖同化测定的生化分析，以表征八种鳞状病症和两种菌株。所有菌株的基因组，包括C. exiguus dsm 14696〜（t）（此处新报告），分享了低于95％的平均核苷酸同一性，数字DNA-DNA杂交得分低于70％，表明它们属于不同的物种。此外，我们表征了每种菌株的牺牲性范围和抗生素抗性曲线，说明了抗微生物活性的多样性，并因此是珊瑚球菌内的药物发现的可能性。每种菌株都具有明显的性质概况，其与其基因组差异支持八个候选菌株作为新种类的提议。八名候选人如下：Corallococcus雌激素SP。 11月。 （AB043A〜（T）= DSM 108849〜（T）= NBRC 113887〜（T）），Corallococcus Intempors SP。 11月。 （AB047A〜（T）= DSM 108843〜（T）= NBRC 113888〜（T）），Corallococcus Aberystwythensis SP。 11月。 （AB050A〜（T）= DSM 108846〜（T）= NBRC 114019〜（T）），CORALLOCCUS PRAEDATOR SP。 11月。 （CA031B〜（T）= DSM 108841〜（T）= NBRC 113889〜（T）），Corallococcus Sicarius SP。 11月。 （CA040B〜（t）= DSM 108850〜（T）= NBRC 113890〜（T）），Corallococcus carmarthensis sp。 11月。 （CA043D〜（T）= DSM 108842〜（T）= NBRC 113891〜（T）），Corallococcus Llansteffanensis SP。 11月。 （CA051B〜（T）= DSM 108844〜（T）= NBRC 114100〜（T））和Corallococcus终结器SP。 11月。 （CA054A〜（T）= DSM 108848〜（T）= NBRC 113892〜（T））。重要性Corallococcus是捕食者的一种具有较大猎物范围的捕食者属，其基因组含有大量的次级代谢物生物合成群。使用一系列分析和测定来表征八个Coralteroccus物种菌株的生理学和进化遗产。多元度量证实，每个应变属于Coralterococcus属内的新型物种。菌株表现出不同的耐药性和掠夺性活动，这反映了它们拥有不同的生物合成基因。在Corallococcus Genus中观察到的抗菌活性的宽度突出了他们对药物发现的潜力，并提出了以前低估了他们的分类多样性和生物技术潜力。将环境分离物分配到新型物种的分类分配使我们能够开始表征这种细菌属的成员的多样性和演变，具有潜在的生物技术重要性，引导未来的生物劝勉努力进行新的生物活性代谢物和抗微生物。

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