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首页> 外文期刊>Applied Microbiology >Airborne Disinfection by Dry Fogging Efficiently Inactivates Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Mycobacteria, and Bacterial Spores and Shows Limitations of Commercial Spore Carriers
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Airborne Disinfection by Dry Fogging Efficiently Inactivates Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Mycobacteria, and Bacterial Spores and Shows Limitations of Commercial Spore Carriers

机译：通过干燥雾化的空气传播有效灭活严重急性呼吸综合征冠状病毒2（SARS-COV-2），分枝杆菌和细菌孢子，并显示出商业孢子载体的局限性

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Airborne disinfection of high-containment facilities before maintenance or between animal studies is crucial. Commercial spore carriers (CSC) coated with 10~(6) spores of Geobacillus stearothermophilus are often used to assess the efficacy of disinfection. We used quantitative carrier testing (QCT) procedures to compare the sensitivity of CSC with that of surrogates for nonenveloped and enveloped viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mycobacteria, and spores, to an aerosolized mixture of peroxyacetic acid and hydrogen peroxide (aPAA-HP). We then used the QCT methodology to determine relevant process parameters to develop and validate effective disinfection protocols (≥4-log_(10) reduction) in various large and complex facilities. Our results demonstrate that aPAA-HP is a highly efficient procedure for airborne room disinfection. Relevant process parameters such as temperature and relative humidity can be wirelessly monitored. Furthermore, we found striking differences in inactivation efficacies against some of the tested microorganisms. Overall, we conclude that dry fogging a mixture of aPAA-HP is highly effective against a broad range of microorganisms as well as material compatible with relevant concentrations. Furthermore, CSC are artificial bioindicators with lower resistance and thus should not be used for validating airborne disinfection when microorganisms other than viruses have to be inactivated.IMPORTANCE Airborne disinfection is not only of crucial importance for the safe operation of laboratories and animal rooms where infectious agents are handled but also can be used in public health emergencies such as the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. We show that dry fogging an aerosolized mixture of peroxyacetic acid and hydrogen peroxide (aPAA-HP) is highly microbicidal, efficient, fast, robust, environmentally neutral, and a suitable airborne disinfection method. In addition, the low concentration of dispersed disinfectant, particularly for enveloped viral pathogens such as SARS-CoV-2, entails high material compatibility. For these reasons and due to the relative simplicity of the procedure, it is an ideal disinfection method for hospital wards, ambulances, public conveyances, and indoor community areas. Thus, we conclude that this method is an excellent choice for control of the current SARS-CoV-2 pandemic.
机译：维护前或动物研究之间的高封闭设施的空中消毒至关重要。涂有10〜（6）孢子的商用孢子载体（CSC）常常用于评估消毒的疗效。我们使用定量载体测试（QCT）程序来比较CSC的敏感性与非共混和包膜病毒的替代品，包括严重的急性呼吸综合征冠状病毒2（SARS-COV-2），分枝杆菌和孢子，雾化混合物过氧乙酸和过氧化氢（APAA-HP）。然后，我们使用QCT方法来确定相关的过程参数，以在各种大型和复杂的设施中开发和验证有效的消毒协议（≥4-log_（10）减少）。我们的结果表明，APAA-HP是空中空间消毒的高效手术。可以无线监控相关的工艺参数，例如温度和相对湿度。此外，我们发现对某些测试的微生物灭活效果的显着差异。总的来说，我们得出结论，干燥雾化APAA-HP的混合物对广泛的微生物以及与相关浓度相容的材料非常有效。此外，CSC是具有较低耐受性的人造生物indInmer，因此当必须灭活的微生物时不应用于验证空气传播的消毒。分析空气传播的消毒不仅对传染性药剂的实验室和动物室的安全操作至关重要被处理，但也可以用于公共卫生紧急情况，如目前的严重急性呼吸综合征冠状病毒2（SARS-COV-2）大流行。我们表明，干燥雾化过氧化物和过氧化氢（APAA-HP）的雾化混合物是高杀微生物，有效，快速，鲁棒，环境中性的，以及合适的空气传播的消毒方法。此外，低浓度的分散消毒剂，特别是对于诸如SARS-COV-2的包膜病毒病原体，需要高材料相容性。由于这些原因，由于该程序的相对简单性，它是医院病房，救护车，公共交通工具和室内社区地区的理想消毒方法。因此，我们得出结论，该方法是控制当前SARS-COV-2大流行的绝佳选择。

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