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首页> 外文期刊>PLoS One >Evaluation of antiviral T cell responses and T SCM cells in volunteers enrolled in a phase I HIV-1 subtype C prophylactic vaccine trial in India
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Evaluation of antiviral T cell responses and T SCM cells in volunteers enrolled in a phase I HIV-1 subtype C prophylactic vaccine trial in India

机译：抗病毒T细胞应答和T SCM细胞在志愿者中注册的I期HIV-1亚型C预防性疫苗审判中的志愿者

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T cells play an important role in controlling viral replication during HIV infection. An effective vaccine should, therefore, lead to the induction of a strong and early viral-specific CD8 + T cell response. While polyfunctional T cell responses are thought to be important contributors to the antiviral response, there is evidence to show that polyfunctional HIV- specific CD8 + T cells are just a small fraction of the total HIV-specific CD8 + T cells and may be absent in many individuals who control HIV replication, suggesting that other HIV-1 specific CD8 + effector T cell subsets may be key players in HIV control. Stem cell-like memory T cells (T SCM ) are a subset of T cells with a long half-life and self-renewal capacity. They serve as key reservoirs for HIV and contribute a significant barrier to HIV eradication. The present study evaluated vaccine-induced antiviral responses and T SCM cells in volunteers vaccinated with a subtype C prophylactic HIV-1 vaccine candidate administered in a prime-boost regimen. We found that ADVAX DNA prime followed by MVA boost induced significantly more peripheral CD8 + T SCM cells and higher levels of CD8 + T cell-mediated inhibition of replication of different HIV-1 clades as compared to MVA alone and placebo. These findings are novel and provide encouraging evidence to demonstrate the induction of T SCM and cytotoxic immune responses by a subtype C HIV-1 prophylactic vaccine administered using a prime-boost strategy.
机译：T细胞在艾滋病毒感染期间控制病毒复制方面发挥着重要作用。因此，有效的疫苗应该导致诱导强烈和早期的病毒特异性CD8 + T细胞反应。虽然多官能T细胞应答被认为是抗病毒反应的重要贡献者，但有证据表明，多官能HIV-特异性CD8 + T细胞仅是总HIV特异性CD8 + T细胞的一小部分，并且可能不存在许多控制HIV复制的人，表明其他HIV-1特异性CD8 +效应T细胞子集可以是HIV控制中的关键播放器。干细胞样记忆T细胞（T SCM）是具有长半衰期和自我更新能力的T细胞的子集。它们作为艾滋病毒的关键储层，为艾滋病毒删除造成显着障碍。本研究评估了用亚型Caphylic HIV-1疫苗候选疫苗疫苗疫苗疫苗的疫苗诱导的抗病毒反应和T SCM细胞，其在初始升压方案中施用。我们发现，与单独的MVA和安慰剂相比，MVA增强诱导MVA增强诱导MVA增强诱导的诱导更高的CD8 + T细胞介导的CD8 + T细胞介导的抑制。这些发现是新颖的，并提供令人鼓舞的证据，证明使用主要促进策略给药的亚型C HIV-1预防疫苗诱导T SCM和细胞毒性免疫应答。

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