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首页> 外文期刊>PLoS One >The effects of prolonged sitting, prolonged standing, and activity breaks on vascular function, and postprandial glucose and insulin responses: A randomised crossover trial
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The effects of prolonged sitting, prolonged standing, and activity breaks on vascular function, and postprandial glucose and insulin responses: A randomised crossover trial

机译：长时间坐，长时间的身份和活动突破对血管功能的影响，以及后葡萄糖和胰岛素反应：随机交叉试验

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The objective of this study was to compare acute effects of prolonged sitting, prolonged standing and sitting interrupted with regular activity breaks on vascular function and postprandial glucose metabolism. In a randomized cross-over trial, 18 adults completed: 1. Prolonged Sitting; 2. Prolonged Standing and 3. Sitting with 2-min walking (5 km/h, 10% incline) every 30 min (Regular Activity Breaks). Flow mediated dilation (FMD) was measured in the popliteal artery at baseline and 6 h. Popliteal artery hemodynamics, and postprandial plasma glucose and insulin were measured over 6 h. Neither raw nor allometrically-scaled FMD showed an intervention effect (p = 0.285 and 0.159 respectively). Compared to Prolonged Sitting, Regular Activity Breaks increased blood flow (overall effect of intervention p0.001; difference = 80%; 95% CI 34 to 125%; p = 0.001) and net shear rate (overall effect of intervention p0.001; difference = 72%; 95% CI 30 to 114%; p = 0.001) at 60 min. These differences were then maintained for the entire 6 h. Prolonged Standing increased blood flow at 60 min only (overall effect of intervention p0.001; difference = 62%; 95% CI 28 to 97%; p = 0.001). Regular Activity Breaks decreased insulin incremental area under the curve (iAUC) when compared to both Prolonged Sitting (overall effect of intervention P = 0.001; difference = 28%; 95% CI 14 to 38%; p0.01) and Prolonged Standing (difference = 19%; 95% CI 4 to 32%, p = 0.015). There was no intervention effect on glucose iAUC or total AUC (p = 0.254 and 0.450, respectively). In normal-weight participants, Regular Activity Breaks induce increases in blood flow, shear stress and improvements in postprandial metabolism that are associated with beneficial adaptations. Physical activity and sedentary behaviour messages should perhaps focus more on the importance of frequent movement rather than simply replacing sitting with standing.
机译：本研究的目的是比较长期坐的急性效果，长时间的血管术后，血管功能和餐后葡萄糖新陈代谢中断。在随机交叉审判中，完成18名成人：1.持续坐; 2.每30分钟（常规活动休息）每隔30分钟，坐在2分钟步行（5公里/小时，10％倾斜）。在基线和6小时的Popliteal动脉中测量流量介导的扩张（FMD）。 Popliteal动脉血流动力学和餐后血浆葡萄糖和胰岛素超过6小时。未经原始的也不缩放的FMD都没有显示出干预效果（分别为p = 0.285和0.159）。与长时间的坐着相比，常规活性破裂增加血流（干预的总体效果P <0.001;差异= 80％; 95％CI 34至125％; P = 0.001）和净剪切速率（干预的总效果P <0.001;差异= 72％; 95％CI 30至114％; p = 0.001）在60分钟。然后为整个6小时维持这些差异。长时间的站立增加血液流动仅在60分钟（干预P <0.001的总体效果;差异= 62％; 95％CI 28至97％; P = 0.001）。与延长坐姿相比，常规活性在曲线（IAUC）下减少胰岛素增量区域（干预P = 0.001的总体效果;差异= 28％; 95％CI 14至38％; P <0.01）和延长的站立（差异= 19％; 95％CI 4至32％，P = 0.015）。对葡萄糖IAC或总AUC的干预效果（P = 0.254和0.450）。在正常权重参与者中，常规活动突破诱导血流，剪切应力和后施加代谢的改善增加，这些代谢与有益适应相关。身体活动和久坐不动的行为消息应该更多地关注频繁运动的重要性，而不是简单地更换坐姿。

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