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首页> 外文期刊>BMC Medical Genomics >Role of ATF3 as a prognostic biomarker and correlation of ATF3 expression with macrophage infiltration in hepatocellular carcinoma
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Role of ATF3 as a prognostic biomarker and correlation of ATF3 expression with macrophage infiltration in hepatocellular carcinoma

机译：ATF3作为预后生物标志物的作用及ATF3表达与肝细胞癌巨噬细胞浸润的相关性

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摘要

The abnormal expression of activating transcription factor 3 (ATF3), a member of the basic leucine zipper (bZIP) family of transcription factors, is associated with carcinogenesis. However, the expression pattern and exact role of ATF3 in the development and progression of hepatocellular carcinoma (HCC) remain unclear. We used UALCAN, ONCOMINE, Kaplan–Meier plotter, and cBioPortal databases to investigate the prognostic value of ATF3 expression in HCC. ATF3 was found to be expressed at low levels in multiple HCC tumor tissues. Moreover, low ATF3 expression was significantly associated with clinical cancer stage and pathological tumor grade in patients with HCC. Therefore, low expression of ATF3 was significantly associated with poor overall survival in patients with HCC. Functional network analysis showed that ATF3 regulates cytokine receptors and signaling pathways via various cancer-related kinases, miRNAs, and transcription factors. ATF3 expression was found to be correlated with macrophage infiltration levels and with macrophage immune marker sets in HCC patients. Using data mining methods, we clarified the role of ATF3 expression and related regulatory networks in HCC, laying a foundation for further functional research. Future research will validate our findings and establish clinical applications of ATF3 in the diagnosis and treatment of HCC.
机译：激活转录因子3（ATF3）的异常表达，碱性亮氨酸ZIPPER（BZIP）转录因子家族的成员与致癌有关。然而，ATF3在肝细胞癌（HCC）的开发和进展中的表达模式和精确作用仍然不清楚。我们使用了Ualcan，Oncomine，Kaplan-Meier绘图仪和Cbioportal数据库来研究HCC中ATF3表达的预后价值。发现ATF3在多个HCC肿瘤组织中以低水平表达。此外，低ATF3表达与HCC患者临床癌症阶段和病理肿瘤等级显着相关。因此，atf3的低表达与HCC患者的整体存活差显着相关。功能网络分析表明，ATF3通过各种癌症相关激酶，miRNA和转录因子调节细胞因子受体和信号通路。发现ATF3表达与巨噬细胞浸润水平和HCC患者中的巨噬细胞免疫标记组相关。使用数据挖掘方法，我们澄清了ATF3表达及相关的监管网络在HCC中的作用，为进一步的功能研究奠定了基础。未来的研究将验证我们的研究结果，并在HCC的诊断和治疗中建立ATF3的临床应用。

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