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首页> 外文期刊>BMC Medical Genomics >Genome-wide analysis of retinal transcriptome reveals common genetic network underlying perception of contrast and optical defocus detection
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Genome-wide analysis of retinal transcriptome reveals common genetic network underlying perception of contrast and optical defocus detection

机译：视网膜转录组的基因组分析揭示了常见的遗传网络潜在的对比度和光学散焦检测

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Refractive eye development is regulated by optical defocus in a process of emmetropization. Excessive exposure to negative optical defocus often leads to the development of myopia. However, it is still largely unknown how optical defocus is detected by the retina. Here, we used genome-wide RNA-sequencing to conduct analysis of the retinal gene expression network underlying contrast perception and refractive eye development. We report that the genetic network subserving contrast perception plays an important role in optical defocus detection and emmetropization. Our results demonstrate an interaction between contrast perception, the retinal circadian clock pathway and the signaling pathway underlying optical defocus detection. We also observe that the relative majority of genes causing human myopia are involved in the processing of optical defocus. Together, our results support the hypothesis that optical defocus is perceived by the retina using contrast as a proxy and provide new insights into molecular signaling underlying refractive eye development.
机译：折射眼部发育是通过光学散焦调节在偏心化过程中。过度接触负光学散焦通常导致近视的发育。然而，它仍然很大程度上是如何通过视网膜检测到光学散焦。这里，我们使用基因组RNA测序来进行视网膜基因表达网络的分析，其对比感性和屈光眼发育。我们报告说，遗传网络对比感知的遗传网络在光学散焦检测和偏心化中起着重要作用。我们的结果表明了对比感知，视网膜昼夜钟通路和潜在光学散焦检测的信号通路之间的相互作用。我们还观察到导致人近视的相对大多数基因涉及光学散焦的处理。我们的结果在一起，支持光学散焦通过视网膜使用对比度作为代理的反射，并为分子信号传导的屈光性屈光度发育提供新的见解。

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