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首页> 外文期刊>BMC Medical Genomics >Comprehensive analysis of prognostic value and immune infiltration of kindlin family members in non-small cell lung cancer
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Comprehensive analysis of prognostic value and immune infiltration of kindlin family members in non-small cell lung cancer

机译：非小细胞肺癌中林林家族预后价值和免疫浸润的综合分析

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Kindlin Family Members have been reported to be aberrantly expressed in various human cancer types and involved in tumorigenesis, tumor progression, and chemoresistance. However, their roles in non-small cell lung cancer (NSCLC) remain poorly elucidated. We analyzed the prognostic value and immune infiltration of Kindlins in NSCLC through Oncomine, GEPIA, UALCAN, CCLE, Kaplan?Meier plotter, cBioPortal, TIMER, GeneMANIA, STRING, and DAVID database. Additionally, the mRNA expression levels of Kindlins were verified in 30 paired NSCLC tissues and NSCLC cell lines by real-time PCR. The expression level of FERMT1 was remarkably increased in NSCLC tissues and NSCLC cell lines, while FERMT2 and FERMT3 were reduced. Kindlins expressions were associated with individual cancer stages and nodal metastasis. We also found that higher expression level of FERMT1 was obviously correlated with worse overall survival (OS) in patients with NSCLC, while higher FERMT2 was strongly associated with better overall survival (OS) and first progression (FP). Additionally, the expression of FERMT2 and FERMT3 were obviously correlated with the immune infiltration of diverse immune cells. Functional enrichment analysis has shown that Kindlins may be significantly correlated with intracellular signal transduction, ATP binding and the PI3K-Akt signaling pathway in NSCLC. The research provides a new perspective on the distinct roles of Kindlins in NSCLC and likely has important implications for future novel biomarkers and therapeutic targets in NSCLC.
机译：据报道，林林家族成员在各种人类癌症类型中表达，并参与肿瘤发生，肿瘤进展和化学性。然而，它们在非小细胞肺癌（NSCLC）中的作用仍然很阐明。我们通过oncomine，Gepia，Ualcan，CCL，Kaplan？Meier绘图仪，CBIOPorter，计时器，GeneMania，String和David数据库，分析了NSCLC中的幼稚苷酸的预后价值和免疫浸润。另外，通过实时PCR在30个配对的NMSCLC组织和NSCLC细胞系中验证了幼稚素的mRNA表达水平。在NSCLC组织和NSCLC细胞系中，FermT1的表达水平显着增加，而FERMT2和FERMT3降低。有点表达与个体癌症阶段和节点转移有关。我们还发现，NSCLC患者的较差的总存活（OS）明显相关，而NSCLC的较差的总存活（OS）明显相关，而较高的FERMT2与更好的整体存活（OS）和第一进展（FP）强烈相关。另外，FermT2和FermT3的表达与不同免疫细胞的免疫浸润明显相关。功能性富集分析表明，在NSCLC中，与细胞内信号转导，ATP结合和PI3K-AKT信号传导途径显着相关。该研究提供了一种新的关视人物在NSCLC中的不同作用，并且可能对NSCLC未来新型生物标志物和治疗目标具有重要意义。

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